“Using molecular dynamic simulations, this study shows that #hydroxychloroquine and #azithromycin act in synergy to prevent any close contact between #SARSCoV2 virus and the plasma membrane of host cells.”

#COVID19Canada #medtwitter https://www.sciencedirect.com/science/article/pii/S0924857920301837

2/ “Molecular mimicry btwn #azithromycin & ganglioside sugar is revealed. Azithromycin binds to the virus spike protein of #SARSCoV2 and #hydroxychloroquine binds to gangliosides. ATM is directed against the virus, whereas HCQ is directed against cellular attachment cofactors.”

3/ “This is consistent w/synergistic antiviral mechanism at plasma membrane level, where therapeutic intervention is likely to be most efficient. This molecular mechanism may explain beneficial effects of #hydroxychloroquine & #azithromycin combination therapy in pts w/ #COVID19”