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“we detected SARS-CoV-2−reactive CD4+ T cells in ∼40-60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2.” https://twitter.com/profshanecrotty/status/1261052353773363200">https://twitter.com/profshane...
81% possess some degree of functional T-cell memory! Only panic is novel…
“Cross-reactivity of T cells for different virus species or even amongst different pathogens is a well-known phenomenon postulated to enable heterologous immunity to a pathogen” https://www.researchsquare.com/article/rs-35331/v1">https://www.researchsquare.com/article/r...
“Cross-reactivity of T cells for different virus species or even amongst different pathogens is a well-known phenomenon postulated to enable heterologous immunity to a pathogen” https://www.researchsquare.com/article/rs-35331/v1">https://www.researchsquare.com/article/r...
“potential precursors were identified in naïve B cell repertoires from 48 healthy individuals that were sampled before the COVID-19 pandemic.” https://www.cell.com/cell/fulltext/S0092-8674(20)30821-7">https://www.cell.com/cell/full...
A summary of peer-reviewed literature (no preprints)
“it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. It is hypothesized, but not yet proven, that this might be due to immunity to CCCs.” https://www.nature.com/articles/s41577-020-0389-z">https://www.nature.com/articles/...
“it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. It is hypothesized, but not yet proven, that this might be due to immunity to CCCs.” https://www.nature.com/articles/s41577-020-0389-z">https://www.nature.com/articles/...
https://twitter.com/naturemedicine/status/1282667130366955520?s=21">https://twitter.com/naturemed... https://twitter.com/NatureMedicine/status/1282667130366955520">https://twitter.com/NatureMed...
https://twitter.com/bertoletti_lab/status/1283330582923997185?s=21">https://twitter.com/bertolett... https://twitter.com/bertoletti_lab/status/1283330582923997185">https://twitter.com/bertolett...
One of the earliest to show T-cell immune memory in non-infected people, but I just came across it. https://www.medrxiv.org/content/10.1101/2020.04.17.20061440v1">https://www.medrxiv.org/content/1...
Press release and final publication https://www.charite.de/en/service/press_reports/artikel/detail/could_prior_exposure_to_common_cold_viruses_affect_the_severity_of_sars_cov_2_symptoms/">https://www.charite.de/en/servic...
https://twitter.com/gerdosi/status/1294622088679034882?s=21">https://twitter.com/gerdosi/s... https://twitter.com/gerdosi/status/1294622088679034882">https://twitter.com/gerdosi/s...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(20)30102-6
(https://www.cell.com/cell-repo... href="https://twitter.com/steph_bernard69">@steph_bernard69 Twitter repeatedly refused to add your post to this thread, but thanks anyway.)
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