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History of clonidine: A small threadAround 1960: Clonidine, an α2-agonist, was developed as a nasal decongestant that worked by vasoconstriction.
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Administered to a secretory, she developed following features along with good nasal decongestant effect at low concentration
Fell asleep for 24 h
Low blood pressure
Marked bradycardia
Dryness of the mouth
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Fell asleep for 24 hLow blood pressureMarked bradycardiaDryness of the mouth2/3
1966: introduced in clinical practice reformulated for hypertension.Source:Helmut Stähle,A historical perspective: development of clonidine, Best Practice & Research Clinical Anaesthesiology, Volume 14, Issue 2, 2000, Pages 237-246, ISSN 1521-6896
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