https://abs.twimg.com/emoji/v2/... draggable="false" alt="📌" title="Pushpin" aria-label="Emoji: Pushpin">History of clonidine: A small thread

Around 1960: Clonidine, an α2-agonist, was developed as a nasal decongestant that worked by vasoconstriction. https://abs.twimg.com/emoji/v2/... draggable="false" alt="👃" title="Nose" aria-label="Emoji: Nose"> #pharmacology #MedStudentTwitter 1/3

Administered to a secretory, she developed following features along with good nasal decongestant effect at low concentration

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📍" title="Round pushpin" aria-label="Emoji: Round pushpin">Fell asleep for 24 h

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📍" title="Round pushpin" aria-label="Emoji: Round pushpin">Low blood pressure

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📍" title="Round pushpin" aria-label="Emoji: Round pushpin">Marked bradycardia

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📍" title="Round pushpin" aria-label="Emoji: Round pushpin">Dryness of the mouth

2/3

https://abs.twimg.com/emoji/v2/... draggable="false" alt="📌" title="Pushpin" aria-label="Emoji: Pushpin">1966: introduced in clinical practice reformulated for hypertension.

Source:Helmut Stähle,A historical perspective: development of clonidine, Best Practice & Research Clinical Anaesthesiology, Volume 14, Issue 2, 2000, Pages 237-246, ISSN 1521-6896
( http://www.sciencedirect.com/science/article/pii/S152168960090079X)3/3">https://www.sciencedirect.com/science/a...