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#SARSCoV2 is neuro-invasive. Is CNS regulation of peripheral catecholamine outflow disrupted in susceptible patients? CAT overflow leading to platelet aggregation: https://www.washingtonpost.com/health/2020/04/22/coronavirus-blood-clots/ Consistent risk-factors for severe #covid19. cc @Peter_vd_Voort
https://www.ahajournals.org/doi/abs/10.1161/01.cir.46.4.698
https://www.ahajournals.org/doi/abs/10.1161/01.cir.46.4.698
Interesting hypothesis on CNS invasive #SARSCoV2.
Many anecdotal reports on nicotine-patch in hospital patients #Covid19. cc @AlexWFriedrich1 @Peter_vd_Voort https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192087/
Many anecdotal reports on nicotine-patch in hospital patients #Covid19. cc @AlexWFriedrich1 @Peter_vd_Voort https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192087/
Reduction peripheral sympathetic outflow. Anti-hypertensive, not hypotensive: Centrally acting only, no peripheral drug-drug interactions. Prevention/treatment thrombo-embolic complications #Covid19?
Ref: Franz Messerli @FranzMesserli
https://journals.lww.com/cardiovascularpharm/fulltext/2000/00004/moxonidine__a_new_and_versatile_antihypertensive.7.aspx
Ref: Franz Messerli @FranzMesserli
https://journals.lww.com/cardiovascularpharm/fulltext/2000/00004/moxonidine__a_new_and_versatile_antihypertensive.7.aspx
Remarkable observation:
cc @AlexWFriedrich1 @Peter_vd_Voort https://twitter.com/falsel_net/status/1263736207881707525
cc @AlexWFriedrich1 @Peter_vd_Voort https://twitter.com/falsel_net/status/1263736207881707525
Also remarkable observation: https://www.nejm.org/doi/full/10.1056/NEJMc2018688?query=RP
Remarkable,
entirely consistent with unanticipated #SARSCoV2 brainstem invasion, possibly antagonising Imidazoline I1 receptors in the RVLM. cc @EricTopol https://jamanetwork.com/journals/jamacardiology/fullarticle/2767649
entirely consistent with unanticipated #SARSCoV2 brainstem invasion, possibly antagonising Imidazoline I1 receptors in the RVLM. cc @EricTopol https://jamanetwork.com/journals/jamacardiology/fullarticle/2767649
Given the fact that #SARSCoV2 is neuro-invasive and/or passes BBB; given fact that Mab's do not pass BBB https://twitter.com/pjobphd/status/1269523177773821952 ; given fact that progression to severe life threatening #COVID19 might be associated with CNS dis-regulation of vital functions, blood pressure, 1/2
glucose metabolism, and hypoxia sensing, more consideration could be given to small molecules, especially when considering known clinical risk factors, and difficulty of designing mab clinical trials with some chance of success 2/2 cc. @EricTopol @pjobphd https://jamanetwork.com/journals/jama/fullarticle/2767383?guestAccessKey=7ac8c16d-569b-43e1-b2be-29f94e165f22&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_06192020
