#SARSCoV2 is neuro-invasive. Is CNS regulation of peripheral catecholamine outflow disrupted in susceptible patients? CAT overflow leading to platelet aggregation: https://www.washingtonpost.com/health/2020/04/22/coronavirus-blood-clots/">https://www.washingtonpost.com/health/20... Consistent risk-factors for severe #covid19. cc @Peter_vd_Voort

https://www.ahajournals.org/doi/abs/10.1161/01.cir.46.4.698">https://www.ahajournals.org/doi/abs/1...
A mysterious blood-clotting complication is killing coronavirus patients

Once thought to be a relatively straightforward respiratory virus, covid-19 is proving to be much more complex and frightening

https://www.washingtonpost.com/health/2020/04/22/coronavirus-blood-clots/
Interesting hypothesis on CNS invasive #SARSCoV2.
Many anecdotal reports on nicotine-patch in hospital patients #Covid19. cc @AlexWFriedrich1 @Peter_vd_Voort https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192087/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192087/
Reduction peripheral sympathetic outflow. Anti-hypertensive, not hypotensive: Centrally acting only, no peripheral drug-drug interactions. Prevention/treatment thrombo-embolic complications #Covid19?
Ref: Franz Messerli @FranzMesserli
https://journals.lww.com/cardiovascularpharm/fulltext/2000/00004/moxonidine__a_new_and_versatile_antihypertensive.7.aspx">https://journals.lww.com/cardiovas...
Remarkable observation:
cc @AlexWFriedrich1 @Peter_vd_Voort https://twitter.com/falsel_net/status/1263736207881707525">https://twitter.com/falsel_ne...
Remarkable https://www.reuters.com/article/us-health-coronavirus-hypertension/blood-pressure-drugs-linked-to-lower-covid-19-mortality-study-idUSKBN23B3FL?feedType=RSS&feedName=healthNews&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+reuters%2FhealthNews+%28Reuters+Health+News%29">https://www.reuters.com/article/u...
Blood pressure drugs linked to lower COVID-19 mortality: study

Widely used drugs to control high blood pressure may help protect against severe COVID-19, a new study found, allaying concerns that they could make the illness caused by the coronavirus worse.

https://www.reuters.com/article/us-health-coronavirus-hypertension/blood-pressure-drugs-linked-to-lower-covid-19-mortality-study-idUSKBN23B3FL?feedType=RSS&feedName=healthNews&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+reuters%2FhealthNews+%28Reuters+Health+News%29
Also remarkable observation: https://www.nejm.org/doi/full/10.1056/NEJMc2018688?query=RP">https://www.nejm.org/doi/full/...
New-Onset Diabetes in Covid-19 | NEJM

Correspondence from The New England Journal of Medicine — New-Onset Diabetes in Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMc2018688?query=RP
Remarkable,
entirely consistent with unanticipated #SARSCoV2 brainstem invasion, possibly antagonising Imidazoline I1 receptors in the RVLM. cc @EricTopol https://jamanetwork.com/journals/jamacardiology/fullarticle/2767649">https://jamanetwork.com/journals/...
Out-of-Hospital Cardiac Arrests and Resuscitations During COVID-19 Pandemic

This cross-sectional study describes the characteristics associated with outpatient cardiac arrests and death during the coronavirus disease 2019 pandemic in New York City.

https://jamanetwork.com/journals/jamacardiology/fullarticle/2767649
Given the fact that #SARSCoV2 is neuro-invasive and/or passes BBB; given fact that Mab& #39;s do not pass BBB https://twitter.com/pjobphd/status/1269523177773821952">https://twitter.com/pjobphd/s... ; given fact that progression to severe life threatening #COVID19 might be associated with CNS dis-regulation of vital functions, blood pressure, 1/2
glucose metabolism, and hypoxia sensing, more consideration could be given to small molecules, especially when considering known clinical risk factors, and difficulty of designing mab clinical trials with some chance of success 2/2 cc. @EricTopol @pjobphd https://jamanetwork.com/journals/jama/fullarticle/2767383?guestAccessKey=7ac8c16d-569b-43e1-b2be-29f94e165f22&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_06192020">https://jamanetwork.com/journals/...
Monoclonal Antibodies for Prevention and Treatment of COVID-19

This Viewpoint discusses the potential role of neutralizing monoclonal antibodies (MAbs) as a treatment for coronavirus disease 2019 (COVID-19) and as a means of prevention in high-risk populations,...

https://jamanetwork.com/journals/jama/fullarticle/2767383?guestAccessKey=7ac8c16d-569b-43e1-b2be-29f94e165f22&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_06192020
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