In healthy adolescents and young adults (n=390 after various exclusions), there were no associations with polygenic risk for schizophrenia 4/n
Although it picks up group differences, in the general population (n=735) this task is unrelated to psychopathology. Here we look at a raft of traits to extend previous null general psychopathology findings by @M_Moutoussis + co 5/n https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006679">https://journals.plos.org/ploscompb...
In sum, RL deficits in first episode psychosis (less so in those at clinical risk for psychosis), but not predicted by polygenic risk for schizophrenia. The study does not support reinforcement learning (as measured by this task) as a psychosis intermediate phenotype 6/n
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