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Pre-print review of saliva (vs. nasopharyngeal swab) for detection of SARS-CoV-2 by PCR in symptomatic patients.
10 studies reviewed (all w/ modest n numbers) with saliva being positive in 31-92% of patients. https://www.medrxiv.org/content/10.1101/2020.05.09.20096354v1.article-metrics
10 studies reviewed (all w/ modest n numbers) with saliva being positive in 31-92% of patients. https://www.medrxiv.org/content/10.1101/2020.05.09.20096354v1.article-metrics
There are a few notable papers relating to saliva/oral collections that weren't in this review, so here's a thread:(please chime in if you're aware of others!)
First from @JClinMicro, Williams et al
Saliva 1:1 in aimes; 84% positive compared to NP swabs http://jcm.asm.org/lookup/doi/10.1128/JCM.00776-20
First from @JClinMicro, Williams et al
Saliva 1:1 in aimes; 84% positive compared to NP swabs http://jcm.asm.org/lookup/doi/10.1128/JCM.00776-20
Non-peer reviewed pre-print from Kojima et al., study done in California.
Self-collected oral fluid and nasal swabs were ~sensitive as NP swabs. Caveat: patients needed to be instructed in collection - effectiveness dropped w/o on-site instruction https://doi.org/10.1101/2020.04.11.20062372
Self-collected oral fluid and nasal swabs were ~sensitive as NP swabs. Caveat: patients needed to be instructed in collection - effectiveness dropped w/o on-site instruction https://doi.org/10.1101/2020.04.11.20062372
Another pre-print, Pasomsub, study done in Thailand directly comparing saliva and NP swabs/throat swabs. 21 pts pos by any method, 19/21 detected by NP/OP swab, 18/21 by saliva. https://doi.org/10.1101/2020.04.17.20070045
I know for a fact that other studies comparing saliva to NP swabs (other collection types) are underway and will hopefully be published/pre-printed soon.
Please add to this thread if there are others.
Please add to this thread if there are others.
