In celebration of women and the many contributions they make every day globally, @ASBMB is taking some time to engage in understanding and prioritizing their health.

https://www.asbmb.org/asbmb-today/science/051020/national-women-s-health-week

#NWHW #FindYourHealth

Gynecological disorders, many of which are chronic and debilitating, affect many women globally. Here I’ll highlight two: polycystic ovary syndrome and endometriosis, as these illnesses often overlap. #NWHW #FindyourHealth

Polycystic ovary syndrome
Liu et al. investigated the role of BMP4 in hyperandrogenism using a female mouse model. BMP4 was found to have a vital role in the control of sex hormone levels, offering potential insights for the management of hyperandrogenism.
https://bit.ly/2YYd1QJ 

Cervical cancer

Yoo et al. show that Cat-1 leads to aggressive cancer-associated tumor growth phenotypes, including metastasis due to its association with the protein paxillin, causing disruptions in the PI3K/AKT/mTOR pathway.

http://dx.doi.org/10.1074/jbc.M116.769190

Breast Cancer
BRCA1 is a human tumor suppressor gene found in many breast cancers. Fernandes et al. provided a systematic analysis of the amino acid substitutions that occur at specified regions within mutated BRCA1.
https://bit.ly/2zziYJr 

Bacterial vaginosis
Bacterial vaginosis is the most common vaginal infection. Robinson et al. investigated activity of Gardnerella vaginalis, a species of bacteria against both synthetic and mucosal glycoproteins relative to the environment seen in humans.
https://bit.ly/3cu8s4J