Premenstrual dysphoric disorder ( #PMDD) or neurosteroid sensitivity is caused, in part, by an abnormal response of the GABA receptors to progesterone and allopregnanolone.
Women with PMDD have a reduced ability to adapt to the normal monthly ups and downs of allopregnanolone because their GABA receptors have a reduced ability to reshuffle their five subunits. https://www.larabriden.com/progesterone-mood-treat-pmdd/">https://www.larabriden.com/progester...
Why Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

Progesterone calms the brain and promotes sleep. At the same time, progesterone might be involved in the mood symptoms of PMDD. How can both things be true?

https://www.larabriden.com/progesterone-mood-treat-pmdd/
I just love sharing the image of the five subunits of the GABA receptor. Like a transformer action figure.
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