Premenstrual dysphoric disorder ( #PMDD) or neurosteroid sensitivity is caused, in part, by an abnormal response of the GABA receptors to progesterone and allopregnanolone.
Women with PMDD have a reduced ability to adapt to the normal monthly ups and downs of allopregnanolone because their GABA receptors have a reduced ability to reshuffle their five subunits. https://www.larabriden.com/progesterone-mood-treat-pmdd/
I just love sharing the image of the five subunits of the GABA receptor. Like a transformer action figure.