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1/ Presymptomatic transmission is one of the most complex parts of controlling the #covid19 epidemic.
Quantitative #covid19 viral loads have been found to be equally high in those with or without symptoms. https://www.nejm.org/doi/full/10.1056/NEJMe2009758
Quantitative #covid19 viral loads have been found to be equally high in those with or without symptoms. https://www.nejm.org/doi/full/10.1056/NEJMe2009758
2/ This @NatureMedicine paper estimated presymptomatic #SARSCoV2 transmission as being responsible for nearly half (44%) of secondary cases. https://www.nature.com/articles/s41591-020-0869-5
3/ A strategy that only focuses on those with symptoms is likely to fall drastically far behind in terms of curtailing transmission.
We need far more testing, likely sequentially a few times over the possible incubation period of 14 days in suspect cases
https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported
We need far more testing, likely sequentially a few times over the possible incubation period of 14 days in suspect cases
https://annals.org/aim/fullarticle/2762808/incubation-period-coronavirus-disease-2019-covid-19-from-publicly-reported
4/ This can be especially difficult if secondary transmission is happening in the home w/ someone who is presymptomatic but near family for extended periods.
We need to quickly understand to what extent family-based clusters are driving US transmission. https://www.washingtonpost.com/outlook/2020/04/21/isolate-home-coronavirus-quarantine/
We need to quickly understand to what extent family-based clusters are driving US transmission. https://www.washingtonpost.com/outlook/2020/04/21/isolate-home-coronavirus-quarantine/
5/ Singapore, which had a resurgence of cases after having an initially strong response, has since begun what seems to be an efficient central isolation strategy w/ nearly 9 out of 10 #covid19 cases being centrally isolated. https://www.straitstimes.com/singapore/9-in-10-coronavirus-patients-housed-in-isolation-facilities
6/ Reducing the window b/w when a *high exposure event* occurred & *quarantine* of the suspect case will be critical to minimizing presymptomatic transmission.
Waiting for symptoms means 2-3 days of possible transmission.
https://www.nature.com/articles/s41591-020-0869-5#Fig1
Waiting for symptoms means 2-3 days of possible transmission.
https://www.nature.com/articles/s41591-020-0869-5#Fig1
