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1/
The Cell paper has failed to discuss the most important
IFITM2- Interferon-induced transmembrane protein
These proteins have viral roles, but also
"in Restriction of M. tuberculosis Infection"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916766/
And guess what also turns up?
Prevotella... https://twitter.com/sanchak74/status/1251522371200008197
The Cell paper has failed to discuss the most important
IFITM2- Interferon-induced transmembrane protein
These proteins have viral roles, but also
"in Restriction of M. tuberculosis Infection"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916766/
And guess what also turns up?
Prevotella... https://twitter.com/sanchak74/status/1251522371200008197
2/
"We found differences in the representation of the genus Prevotella within the Prevotellaceae family, showing significant increase in abundance in IFITM3‐deficient and IFITMdel−/− mice." https://onlinelibrary.wiley.com/doi/full/10.1111/imcb.12000
"We found differences in the representation of the genus Prevotella within the Prevotellaceae family, showing significant increase in abundance in IFITM3‐deficient and IFITMdel−/− mice." https://onlinelibrary.wiley.com/doi/full/10.1111/imcb.12000
3/
Also, "A host of viruses and pseudoviruses are not restricted by IFITM proteins."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295558/
(not sure if SARS-Cov2 is part of that, pls check)
Here are the proteins sorted on the counts https://sanchakblog.wordpress.com/2020/04/20/highly-expressed-mrna-in-deceased-74-yr-old-covid19-lung-sample/
Also, "A host of viruses and pseudoviruses are not restricted by IFITM proteins."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295558/
(not sure if SARS-Cov2 is part of that, pls check)
Here are the proteins sorted on the counts https://sanchakblog.wordpress.com/2020/04/20/highly-expressed-mrna-in-deceased-74-yr-old-covid19-lung-sample/
4/
And ferritin? Everything points to a bacterial infection.
"Gram -ve lung pathogens such as H. influenza have developed strategies to acquire iron by using iron-containing human proteins such as tranferrin, lactoferrin, haemoglobin and ferritin" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666040/
And ferritin? Everything points to a bacterial infection.
"Gram -ve lung pathogens such as H. influenza have developed strategies to acquire iron by using iron-containing human proteins such as tranferrin, lactoferrin, haemoglobin and ferritin" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666040/
And they see low Type I and III interferons and elevated chemokines (true, see above) & thus
"reduced innate antiviral defenses"
but cant make the connection to bacterial infection.
"reduced innate antiviral defenses"
but cant make the connection to bacterial infection.
