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Part 1:
Could #ventilatorinducedlunginjury be worsening COVID19 patient health?
Potential #COVID19 drugs include #IL6inhibitors #tocilizumab and #sarilumab — #biologics that may improve lung tissue damage caused by #cytokinerelease in patients with *severe* viral infection.
Could #ventilatorinducedlunginjury be worsening COVID19 patient health?
Potential #COVID19 drugs include #IL6inhibitors #tocilizumab and #sarilumab — #biologics that may improve lung tissue damage caused by #cytokinerelease in patients with *severe* viral infection.
When reading #pharmacological studies, don’t ignore the population description — “critical” #COVID19 patients are more likely to be hooked up to #ventilators.
Are these “miracle drugs” treating the #primarycause or mitigating the iatrogenic effects of mechanical ventilation?
Are these “miracle drugs” treating the #primarycause or mitigating the iatrogenic effects of mechanical ventilation?
#COVID19 part 3:
(I’m speaking from the perspective and experience of a student with a curious mind. I’m not a conspiracy theorist, nor would I ever withhold ventilation from a patient in respiratory distress.
However, I believe injury-reducing strategies should be considered).
(I’m speaking from the perspective and experience of a student with a curious mind. I’m not a conspiracy theorist, nor would I ever withhold ventilation from a patient in respiratory distress.
However, I believe injury-reducing strategies should be considered).
#COVID19 part 4:
Among several targets of developing #pharmaceutical agents are: #interleukin8, #tnfalpha, #interleukin6, #interleukin1, and other inflammatory mediators.
Interestingly, ventilation-induced lung injury causes the release of IL1, IL6, IL8, and TNF-alpha...
Among several targets of developing #pharmaceutical agents are: #interleukin8, #tnfalpha, #interleukin6, #interleukin1, and other inflammatory mediators.
Interestingly, ventilation-induced lung injury causes the release of IL1, IL6, IL8, and TNF-alpha...
#COVID19 part 5:
Though drugs that target these mediators already exist, novel therapies (including #biologics) are now in development.
And while I’m proud of this progress, creating these treatments will be incredibly costly, both in terms of money as well as time.
Though drugs that target these mediators already exist, novel therapies (including #biologics) are now in development.
And while I’m proud of this progress, creating these treatments will be incredibly costly, both in terms of money as well as time.
#COVID19 part 6:
I’ve heard many people say, “when ‘this’ is all over...” as if “this” is something that will just end.
A “miracle drug” is unlikely. I know we all want one.
But we can’t just wait for “this” to pass. We need to adapt & compromise, in the safest ways we can.
I’ve heard many people say, “when ‘this’ is all over...” as if “this” is something that will just end.
A “miracle drug” is unlikely. I know we all want one.
But we can’t just wait for “this” to pass. We need to adapt & compromise, in the safest ways we can.
#COVID19 part 7:
I am not a doctor, but I have a degree in #moleculargenetics and #publichealth.
I think we could focus on #ventilation strategies — O2 via nasal cannula (mild cases), #ECMO (severe cases), etc.
We’re providing O2 but not eliminating CO2 at a fast enough rate.
I am not a doctor, but I have a degree in #moleculargenetics and #publichealth.
I think we could focus on #ventilation strategies — O2 via nasal cannula (mild cases), #ECMO (severe cases), etc.
We’re providing O2 but not eliminating CO2 at a fast enough rate.
#COVID19 part 8:
This virus affects the blood. Its mechanism involves “hijacking” heme (higher prevalence in males? Males have naturally higher hemoglobin levels & iron levels).
Blood pH is another factor— there’s a correlation between blood acidity & infection rate.
This virus affects the blood. Its mechanism involves “hijacking” heme (higher prevalence in males? Males have naturally higher hemoglobin levels & iron levels).
Blood pH is another factor— there’s a correlation between blood acidity & infection rate.
#COVID19 part 9:
Another interesting finding: drugs that have been found to be useful are also drugs that make blood more acidic (lower pH, raise anion gap, etc.)
Also, several drugs increase the concentration of #methemoglobin and decrease concentration of #hemoglobin...
Another interesting finding: drugs that have been found to be useful are also drugs that make blood more acidic (lower pH, raise anion gap, etc.)
Also, several drugs increase the concentration of #methemoglobin and decrease concentration of #hemoglobin...
#COVID19 part 10:
I’d be interested to see if there has been work done studying the prevalence/severity of cases in #anemic populations or in groups with #hemoglobinopathies like #sicklecellanemia or #hereditaryhemochromatosis
Any #hematologists who could weigh in?
I’d be interested to see if there has been work done studying the prevalence/severity of cases in #anemic populations or in groups with #hemoglobinopathies like #sicklecellanemia or #hereditaryhemochromatosis
Any #hematologists who could weigh in?
#COVID19 part 11:
Continuing from the #hematology side... could #erythropoeitin be of any use in certain cases? I’ve read that anemia develops as a complication of this virus, but could increasing red blood cell production be a possible treatment?
Continuing from the #hematology side... could #erythropoeitin be of any use in certain cases? I’ve read that anemia develops as a complication of this virus, but could increasing red blood cell production be a possible treatment?
#COVID19 part 11.5:
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25839">https://onlinelibrary.wiley.com/doi/pdf/1...
Here’s a paper citing the use of recombinant human erythropoietin ( #rhEPO). Though as it was co-administered with an anti-viral, the effects of rhEPO alone can’t be entirely elucidated from this study.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.25839">https://onlinelibrary.wiley.com/doi/pdf/1...
Here’s a paper citing the use of recombinant human erythropoietin ( #rhEPO). Though as it was co-administered with an anti-viral, the effects of rhEPO alone can’t be entirely elucidated from this study.
#COVID19 part 12:
This virus has also been said to present similarly to altitude sickness or carbon monoxide poisoning (in blood arterial gas results and general symptoms)— of course #ecmo is a last-line treatment, but removing CO2 should remain a focus. O2 alone is not enough.
This virus has also been said to present similarly to altitude sickness or carbon monoxide poisoning (in blood arterial gas results and general symptoms)— of course #ecmo is a last-line treatment, but removing CO2 should remain a focus. O2 alone is not enough.
#COVID19 part 13:
I’ll end this thread by again stating that all I’ve said is speculation, based on reading papers & studying the mechanisms of this virus.
If anyone has the expertise to weigh in on any of these thoughts, please go ahead— I’d appreciate your insight.
I’ll end this thread by again stating that all I’ve said is speculation, based on reading papers & studying the mechanisms of this virus.
If anyone has the expertise to weigh in on any of these thoughts, please go ahead— I’d appreciate your insight.
