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Thread (1/6)
Good as Gold or Too Good to Be True?
Interesting preprint out today shows that the FDA-approved gold-based drug auranofin, strongly inhibits novel coronavirus (SARS-COV-2) replication while markedly attenuating inflammation in human cells.
https://www.biorxiv.org/content/10.1101/2020.04.14.041228v1.full.pdf">https://www.biorxiv.org/content/1...
Good as Gold or Too Good to Be True?
Interesting preprint out today shows that the FDA-approved gold-based drug auranofin, strongly inhibits novel coronavirus (SARS-COV-2) replication while markedly attenuating inflammation in human cells.
https://www.biorxiv.org/content/10.1101/2020.04.14.041228v1.full.pdf">https://www.biorxiv.org/content/1...
Thread (2/6)
Auranofin is orally available and used to treat patients with early or mild rheumatoid arthritis. MOA is uncertain but may involve inhibition of IκB kinase (IKK) and thioredoxin reductase blocking neutrophil activation and decreasing oxygen free radical production.
Auranofin is orally available and used to treat patients with early or mild rheumatoid arthritis. MOA is uncertain but may involve inhibition of IκB kinase (IKK) and thioredoxin reductase blocking neutrophil activation and decreasing oxygen free radical production.
Thread (3/6)
Recently, researchers @UCSDMedSchool and @UCSDSkaggsSOP discovered broad-spectrum antiparasitic activity of auranofin vs. pathogens causing Giardiasis, Amebiasis, Onchocerciasis, Filiariasis, and the drug has entered clinical trials for this promising indication.
Recently, researchers @UCSDMedSchool and @UCSDSkaggsSOP discovered broad-spectrum antiparasitic activity of auranofin vs. pathogens causing Giardiasis, Amebiasis, Onchocerciasis, Filiariasis, and the drug has entered clinical trials for this promising indication.
Thread (4/6)
Our own lab helped scientists @ScrippsResearch and its nonprofit translational research institute Calibr show auranofin has broad spectrum antibacterial activity against resistant pathogens including M. tuberculosis and MRSA
https://www.pnas.org/content/112/14/4453">https://www.pnas.org/content/1...
Our own lab helped scientists @ScrippsResearch and its nonprofit translational research institute Calibr show auranofin has broad spectrum antibacterial activity against resistant pathogens including M. tuberculosis and MRSA
https://www.pnas.org/content/112/14/4453">https://www.pnas.org/content/1...
Thread (5/6)
Can a single golden drug, AURANOFIN, really treat autoimmune diseases, Alzheimer’s, Parkinson’s, cancer, many resistant bacteria, fungi and parasites, HIV-AIDS, and also be the answer to COVID-19?
Can a single golden drug, AURANOFIN, really treat autoimmune diseases, Alzheimer’s, Parkinson’s, cancer, many resistant bacteria, fungi and parasites, HIV-AIDS, and also be the answer to COVID-19?
Thread (6/6)
Or are we becoming a little too attached to this golden dream, just like Rachel Brosnahan was to her golden arm https://twitter.com/zachraffio/status/1250273191810875392?s=20">https://twitter.com/zachraffi...
Or are we becoming a little too attached to this golden dream, just like Rachel Brosnahan was to her golden arm https://twitter.com/zachraffio/status/1250273191810875392?s=20">https://twitter.com/zachraffi...
