Partial leptin deficiency confers resistance to diet-induced obesity i... https://www.sciencedirect.com/science/article/pii/S2212877820300697

It's almost like the insulin story... cc: @JimJohnsonSci

Their model: "we conclude that in leptin sensitive states, as observed in young and lean animals, reducing leptin level leads to modest increases in food intake and weight gain;

...in contrast, in states of leptin resistance, such as observed in diet-induced obesity, reducing leptin levels restores leptin sensitivity, leading to reduced food intake and body weight gain, accompanied by increased glucose tolerance and insulin sensitivity."