Another multi centric open label Randomized controlled clinical trial on 150 patients treated with #hydroxychloroquine (HCQ) versus standard care for #COVID19

In short: No ≠ between HCQ and non HCQ for viral load and clinical outcome

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https://www.medrxiv.org/content/10.1101/2020.04.10.20060558v1">https://www.medrxiv.org/content/1...
This is a multi center (16 centers), randomized, parallel, open-label, trial of oral HCQ in #COVID19 hospitalized patients.

Incl criteria: >18 y/o, #SARSCoV2 +, in hospital, consent, no prior treatment

Excl criteria: allergy, pregnancy...
Outcome:

#SARSCoV2 viral load at 4,7,10,14,21,28 days

Clinical outcome: clinical symptoms (fever, SpO2, cough

Biology outcome: CRP, ESR, IL-6, TNFa
191 participants -> 41 excluded

150 randomized

HCQ group (75) -> 1, 200 mg daily for three days followed by a
maintained dose of 800 mg daily for the remaining days -> 2or 3 weeks

Non HCQ group(75) -> standard of care

Patient characteristic similar between the two groups
Primary outcome #SARSCoV2 tests. No difference in outcome between HCQ 85% vs SOC 81%. No ≠ at any time point
Secondary outcome: Symptoms: Again no ≠ between HCQ and SOC in alleviation of symptoms except maybe in the 2nd week of treatment
Biol outcome: CRP lower in HCQ group
Safety: significant adverse events in the HCQ group (7 patients) vs 2 patients in SOC.
Commonly diarrhea. 1 HCQ patient discontinued due t blurred vision
Cardiac side effects not checked
In conclusion from this multi centric RCT: Overall relatively well performed

No difference in clinical outcome or viral load between HCQ and non HCQ group
Lower CRP value and less lymphopenia in HCQ group but we don& #39;t treat biological values in medicine
Finally from the last sets of randomized clinical trials I cannot see a clear benefit of HCQ administration to #COVID19 patients. Safety is still a concern. Of course accumulation of data will give a better picture of HCQ efficacy

For now HCQ is not as promising as advertised
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