1/n. COVID-break. New publication from the Choi lab! Congrats to @jay__daniels and @petergdoukas for their hard work! Details below!
Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas http://disq.us/t/3nsysco ">https://disq.us/t/3nsysco...

2/n. Cutaneous gamma delta T cell lymphomas (CGDTLs) are poorly understood highly aggressive but heterogeneous lymphomas of the skin-homing gamma delta T cell. Through creativity and hard work, @Jay___Daniels and @petergdoukas uncovered the drivers of disease heterogeneity.

3/n. Take home messages! 1) Differences in cell of origin drive CGDTLs& #39; clinical heterogeneity. Epidermal and dermal CGDTLs are derived from V delta 1 gd T cells. Panniculitic CGDTLs are derived from a new cell type we discovered, the V gamma 3 V delta 2 gd T cell.

4/n. 2) For example, V delta 2 lymphomas make more IFN-g and cytotoxic markers. Correspondingly, cytokine driven paraneoplastic syndromes such as hemophagocytic lymphohistiocytosis (HLH) only occur in patients with V delta 2 lymphomas.