BREAKING: #remdesivir shows encouraging preliminary results for #COVID19:

68% (36 of 53 patients) had improvement in oxygen support; only 15% worsened
57% (17 of 30) on ventilators taken OFF
3 of 4 on ECMO (*extremely* ill) taken OFF

#coronavirus https://www.washingtonpost.com/business/2020/04/10/gileads-experimental-drug-remdesivir-shows-hopeful-signs-small-group-coronavirus-patients/?utm_campaign=wp_main&utm_medium=social&utm_source=twitter

No new safety signals, but 13% of these severely ill #COVID19 patients died.

These preliminary results from this compassionate-use study need to be confirmed in placebo-controlled trials –but these are already underway!

@NEJM #coronavirus #remdesivir https://www.nejm.org/doi/full/10.1056/NEJMoa2007016?query=RP

Another antiviral drug with the same mechanism of action ( #galidesivir) is also being studied in a well designed, randomized, placebo-controlled clinical trial.

The scientists are ON it.

#COVID19 #coronavirus https://twitter.com/DrDenaGrayson/status/1248673895126691841?s=20

MORE on #galidesivir: it showed preclinical activity against #SARS (closely related to the #coronavirus), #Ebola and other deadly viruses.

I worked for YEARS on #galidesivir, and now it's being studied in a clinical trial of #COVID19 patients. https://twitter.com/DrDenaGrayson/status/1248675876818030592?s=20

#Favipiravir: a 3rd drug that works similarly to #remdesivir and #galidesivir showed efficacy against #COVID19.

The drugs block the virus’ ability to make RNA copies needed for new viral particles, so it’s plausible they'll work against #coronavirus. https://twitter.com/DrDenaGrayson/status/1240257063504281602?s=20