Thread by @DrDenaGrayson, BREAKING: Good news! Preliminary study of 10 patients with severe #COVID19 shows [...]

Dena Grayson, MD, PhD

DrDenaGrayson

BREAKING: Good news! Preliminary study of 10 patients with severe #COVID19 shows that after 1 dose of convalescent plasma:

Virus disappeared in blood in 7 days

Clinical symptoms rapidly improved within 3 days

Lung lesions improves within 7 days https://www.technologyreview.com/2020/04/08/998700/blood-plasma-taken-from-covid-19-survivors-might-help-patients-fight-it-off/

Blood plasma taken from covid-19 survivors might help patients fight it off

Transfusions of blood serum from people who’ve recovered from covid-19 could help severe cases recover, according to a new study from China. Plasma donation: The concept of using blood from survivo...

https://www.technologyreview.com/2020/04/08/998700/blood-plasma-taken-from-covid-19-survivors-might-help-patients-fight-it-off/

The study in #China was NOT randomized, so these results must be confirmed in larger studies.

These preliminary results are encouraging: several patients cleared the #coronavirus entirely, suggesting that plasma “can serve as a promising rescue option” for severe #COVID19 cases.

Here is a link to the peer-reviewed study, published in @PNASNews: https://www.pnas.org/content/early/2020/04/02/2004168117

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

COVID-19 is currently a big threat to global health. However, no specific antiviral agents are available for its treatment. In this work, we explore the feasibility of convalescent plasma (CP)...

https://www.pnas.org/content/early/2020/04/02/2004168117

The viral load was *undetectable* after transfusion in 7 patients who had previous viremia (virus in blood).

Several lab parameters tended to improve: lymphocyte counts and C-reactive protein. Radiological exams showed varying degrees of absorption of lung lesions within 7 d.

Althought these PRELIMINARY results are encouraging, they *must* be confirmed in larger studies....

Good news: these studies of #convalescentplasma are already underway here in the US!

#coronavirus #COVID19 #CoronavirusPandemic
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