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PLASMA TRANSFUSION: Whoa - plasma from recovered #COVID19 patients tested in 10 severe cases showed that 1 dose (200 mL) of CP could increase or maintain the neutralizing antibodies at a high level, symptoms improved in 3 days, w/ viral load gone in 7 d. https://www.pnas.org/content/early/2020/04/02/2004168117
2) “No severe adverse effects were observed. These results indicate that CP can serve as a promising rescue option for severe COVID-19, while the randomized trial is warranted.” #COVID19
3) Prior to CP treatment, 3 patients had mechanical ventilation, 3 had high-flow nasal cannula oxygenation. All symptoms in the 10 patients, especially fever, cough, shortness of breath, and chest pain, disappeared or largely improved within 1-3 days upon CP transfusion. #COVID19
4) After CP treatment, 2 patients were weaned from mechanical ventilation to high-flow nasal cannula, and one patient discontinued high-flow nasal cannula. in one patient treated with conventional nasal oxygenation, continuous oxygenation was shifted to intermittent oxygenation.
5) on chest CTs, all patients showed different degrees of absorption of pulmonary lesions after CP transfusion. Ie. lesions disappeared.
