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Rapid IgM/IgG Testing for #COVID19
https://www.ncbi.nlm.nih.gov/pubmed/32104917
Currently RT-PCR, CT imaging and blood work parameters (i.e. ferritin, d-dimer, lymphopenia, etc…) are used to diagnose infection BUT...there are major issues with RT-PCR
#COVID19FOAM
https://www.ncbi.nlm.nih.gov/pubmed/32104917
Currently RT-PCR, CT imaging and blood work parameters (i.e. ferritin, d-dimer, lymphopenia, etc…) are used to diagnose infection BUT...there are major issues with RT-PCR
#COVID19FOAM
RT-PCR Limitations:
Long turnaround times
Require certified labs & expensive equipment
Many false negatives
Long turnaround times
Require certified labs & expensive equipment
Many false negatives
525 Cases Tested
397 positive RT-PCR
128 negative RT PCR
352/397 tested positive = Sensitivity of 88.66%
256/397 (64.48%) had both IgM and IgG Abs
12/128 tested positive = Specificity of 90.63%
397 positive RT-PCR
128 negative RT PCR
352/397 tested positive = Sensitivity of 88.66%
256/397 (64.48%) had both IgM and IgG Abs
12/128 tested positive = Specificity of 90.63%
Also tested fingerstick vs peripheral blood in 10 patients
7 COVID-19 positive
3 Healthy volunteers
3 pts IGM only
4 pts IgM & IgG positive
All healthy volunteers negative
7 COVID-19 positive
3 Healthy volunteers
3 pts IGM only
4 pts IgM & IgG positive
All healthy volunteers negative
Detection of IgM and IgG combined into one test can give valuable info on time from virus exposure and provide info on virus infection time course
Bottom Line: Compared to RT-PCR, Rapid IgM/IgG
Faster (15min)
Simple to perform
No additional equipment required
Can be performed at the bedside or any clinic
Can also screen asymptomatic SARS-CoV-2 carriers
Faster (15min)
Simple to perform
No additional equipment required
Can be performed at the bedside or any clinic
Can also screen asymptomatic SARS-CoV-2 carriers
For more on this topic checkout REBEL EM: COVID-19 - Laboratory and Imaging Abnormalities https://rebelem.com/covid-19-laboratory-and-imaging-abnormalities/ #FOAMed
