Thread by @ChrisPerryMito, Now that our book chapter is submitted on reactive oxygen species regulation [...]

Now that our book chapter is submitted on reactive oxygen species regulation in skeletal muscle during exercise, the fun of sharing papers we loved the most can now commence! I& #39;ll start, and @cat_bellissimo can add! String to follow:

Topic 1: Xanthine oxidase as a source of ROS after exercise. Pioneering work by Ylva Hellsten from 1988 (A-V differences purine nucleotide release) up to 1997 (XO increases in endothelial cells and leucocytes post-damaging exercise

https://www.ncbi.nlm.nih.gov/pubmed/3239420
https://www.ncbi.nlm.nih.gov/pubmed/32... href=" https://www.ncbi.nlm.nih.gov/pubmed/9023782 ">https://www.ncbi.nlm.nih.gov/pubmed/90...

Topic 4: The incredible potential for peroxiredoxins to serve as mediators of muscle adaptation through their role as antioxidants...exciting ideas by @ajwadders in this review:

https://www.ncbi.nlm.nih.gov/pubmed/26748042 ">https://www.ncbi.nlm.nih.gov/pubmed/26...

Topic 2: NADPH oxidase-derived ROS increases during contraction in single fibres, but NOT mitochondrial ROS. Several studies, but here are some favourites:

By @malcolm_mjj https://www.ncbi.nlm.nih.gov/pubmed/23050834
By">https://www.ncbi.nlm.nih.gov/pubmed/23... @MuscleBiology @tejensen23 NOX regulates glucose uptake
https://www.ncbi.nlm.nih.gov/pubmed/31604916 ">https://www.ncbi.nlm.nih.gov/pubmed/31...

Also, the 2nd study above by @MuscleBiology and @tejensen23 used a powerful in vivo model to detect NOX-2 activity

Topic 3: Emerging roles of thioredoxins as critical regulators of redox homeostasis and metabolism in muscle following exercise. It& #39;s not just about glutathione. By @KFW_Lab

https://www.ncbi.nlm.nih.gov/pubmed/?term=fisher-wellman+thioredoxin+2013">https://www.ncbi.nlm.nih.gov/pubmed/...

Last but not least, excellent teaching resources on the regulation of mitochondrial bioenergetics: more than just ROS and ATP production

Bioenergetics 4 by David Nicholls, Ferguson
https://www.elsevier.com/books/bioenergetics/nicholls/978-0-12-388425-1
The">https://www.elsevier.com/books/bio... Bioenergetics of Exercise by P.D. Neufer https://www.ncbi.nlm.nih.gov/pubmed/28490536 ">https://www.ncbi.nlm.nih.gov/pubmed/28...

Topic 6: contemporary views of oxidative stress. Let& #39;s move beyond & #39;ROS bad, antioxidants good& #39;. Location, location, location. Type, source, and circuits, circuits, circuits. Examples from Dean Jones:

https://www.ncbi.nlm.nih.gov/pubmed/18684987
https://www.ncbi.nlm.nih.gov/pubmed/18... href=" https://www.ncbi.nlm.nih.gov/pubmed/23861437
https://www.ncbi.nlm.nih.gov/pubmed/23... href=" https://www.ncbi.nlm.nih.gov/pubmed/23946468 ">https://www.ncbi.nlm.nih.gov/pubmed/23...

Topic 2 cont.: One of my all-time favourite studies on ROS-signaling feedback loops with direct protein-oxidation detection. NOX-derived ROS activates glutathione reductase to maintain glutathione: think & #39;ROS-antioxidant activation loop& #39;. By
@Mito_DB
https://ncbi.nlm.nih.gov/pubmed/23341578 ">https://ncbi.nlm.nih.gov/pubmed/23...

Topic 5: the redox-sensitive proteome (& #39;redoxome& #39;). Too many studies to list that reveal the specific proteins that are known to be ROS-sensitive, yet most have not been investigates int terms of how ROS regulates their activities, let alone in response to exercise. Untapped.

Topic 4b cont& #39;d: peroxiredoxins may also serve as inducers of immune activation (role in tissue regeneration/repair?) as speculated by @ajwadders...see molecular example here of how this may happen:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Riddell+JR%2C+Wang+XY%2C+Minderman+H%2C+and+Gollnick+SO.+Peroxiredoxin+1+stimulates+secretion+of+proinflammatory+cytokines+by+binding+to+TLR4.+J+Immunol+184%3A+1022-1030%2C+2010.">https://www.ncbi.nlm.nih.gov/pubmed/...

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