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Once again, here a former FDA commish say hcq has 'significant toxicity', but yet the informed consents for covid trials say they are relatively safe. Which is it?
(it's the latter, a brief thread). https://twitter.com/MedResJourno/status/1247258190884089859
(it's the latter, a brief thread). https://twitter.com/MedResJourno/status/1247258190884089859
first, any drug can kill you. tylenol. aspirin. blood thinners. antibiotics, etc. depends on how much you take, and how rare the side effect is.
second, i am not recommending anyone use this or not.
third, I am not rudy guiliani. i think about drug safety a lot.
second, i am not recommending anyone use this or not.
third, I am not rudy guiliani. i think about drug safety a lot.
does the drug cause blindness?
this is from the American Academy of Opthalmology on retinal toxicity. RARE. look at the y axis, and then look at the x axis, which starts at 5 *years* of therapy. no reason to suspect it's an issue with covid.
https://www.aao.org/clinical-statement/revised-recommendations-on-screening-chloroquine-h
this is from the American Academy of Opthalmology on retinal toxicity. RARE. look at the y axis, and then look at the x axis, which starts at 5 *years* of therapy. no reason to suspect it's an issue with covid.
https://www.aao.org/clinical-statement/revised-recommendations-on-screening-chloroquine-h
does the drug cause Arrhythmia? Is Arrhythmia the hardest word to spell in medicine? Yes and Yes.
Can it happen, yes. Should it be monitored when drug used, yes. Is it rare, yes. From ACC
https://www.acc.org/latest-in-cardiology/articles/2020/03/27/14/00/ventricular-arrhythmia-risk-due-to-hydroxychloroquine-azithromycin-treatment-for-covid-19
Can it happen, yes. Should it be monitored when drug used, yes. Is it rare, yes. From ACC
https://www.acc.org/latest-in-cardiology/articles/2020/03/27/14/00/ventricular-arrhythmia-risk-due-to-hydroxychloroquine-azithromycin-treatment-for-covid-19
here is a preprint from NYU, 1200 words on 84 patients treated for covid with HCQ/Azithro. Yes some prolongation of QT. no arrhythmias. https://www.medrxiv.org/content/10.1101/2020.04.02.20047050v1
I planned poorly and cannot finish this thread.
I think it is a disservice to overhype the benefits of the drug, and a disservice to overhype the risks.
I advise you listen to nice podcast from @DavidJuurlink on other risks from hcq. https://edhub.ama-assn.org/jn-learning/audio-player/18337225
I think it is a disservice to overhype the benefits of the drug, and a disservice to overhype the risks.
I advise you listen to nice podcast from @DavidJuurlink on other risks from hcq. https://edhub.ama-assn.org/jn-learning/audio-player/18337225
one more: clearly, other than anecdote and the preprints, we don't have certainty on risks of hcq in covid. But there is no evidence right now that the drug is any more dangerous than the decades of experience have told us it is. This says nothing of benefits, just the risks.
