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1. Regarding Hydroxychloroquine Trial in NY
Like most of you, I am hoping dearly that the trial proves to be an overwhelming success.
I also know many people, quite understandably, are anxious to get weekly, if not daily or even hourly, updates on how the trial is going.
Like most of you, I am hoping dearly that the trial proves to be an overwhelming success.
I also know many people, quite understandably, are anxious to get weekly, if not daily or even hourly, updates on how the trial is going.
2. Regarding Hydroxychloroquine Trial in NY
Out of frustration with not getting such updates, many people are also reading something sinister into it. Based on my knowledge of clinical trials, I want to make a couple of points, which I invite others in the field to weigh in on.
Out of frustration with not getting such updates, many people are also reading something sinister into it. Based on my knowledge of clinical trials, I want to make a couple of points, which I invite others in the field to weigh in on.
3. Regarding Hydroxychloroquine Trial in NY
First of all, I don't believe anything sinister is going on. Please do not expect any interim updates on how the trial is going that has any scientific basis. Anecdotal hearsay is not always wrong, but that is all you are going to get.
First of all, I don't believe anything sinister is going on. Please do not expect any interim updates on how the trial is going that has any scientific basis. Anecdotal hearsay is not always wrong, but that is all you are going to get.
4. Regarding Hydroxychloroquine Trial in NY
Personally, I will be horrified if I got any update, based on any leaked information, on how the trial was going. Why? Because that would mean we will have to start the trial all over again, losing precious time.
Personally, I will be horrified if I got any update, based on any leaked information, on how the trial was going. Why? Because that would mean we will have to start the trial all over again, losing precious time.
5. Regarding Hydroxychloroquine Trial in NY
While the math is a little complicated, suffice it to say that there is a very good reason no clinical trial provides an interim update on the efficacy of the drug being tested, except ...
While the math is a little complicated, suffice it to say that there is a very good reason no clinical trial provides an interim update on the efficacy of the drug being tested, except ...
6. Regarding Hydroxychloroquine Trial in NY
... if it is a very long trial, with an interim update designed in from the very beginning of the trial. I have never ever come across a short duration clinical trial with even a single interim update, let alone more frequent ones.
... if it is a very long trial, with an interim update designed in from the very beginning of the trial. I have never ever come across a short duration clinical trial with even a single interim update, let alone more frequent ones.
7. Regarding Hydroxychloroquine Trial in NY
The reason is simple. An interim update either invalidates the trial altogether, or raises the statistical bar for a successful outcome so high that it is better to wait for the trial to complete before doing a readout of results.
The reason is simple. An interim update either invalidates the trial altogether, or raises the statistical bar for a successful outcome so high that it is better to wait for the trial to complete before doing a readout of results.
8. Regarding Hydroxychloroquine Trial in NY
What I said is pure math, no politics, and applies universally to all clinical trials.
That said, there are two cases in which an interim update is provided.
What I said is pure math, no politics, and applies universally to all clinical trials.
That said, there are two cases in which an interim update is provided.
