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I was going to write about whether there is any good evidence for chloroquine in the treatment of COVID19. There is none yet, and it might be *harmful*. This is why we need RCTs. My thread would not have been better than this: https://annals.org/aim/fullarticle/2764199/use-hydroxychloroquine-chloroquine-during-covid-19-pandemic-what-every-clinician via @JYazdanyMD @AnnalsofIM
More sober-minded assessment of the possible efficacy of chloroquine for COVID19 via @Dereklowe https://blogs.sciencemag.org/pipeline/archives/2020/04/06/hydroxychloroquine-update-for-april-6 We could easily harm people by using this drug on a wide scale.
This behavior of high-profile recommendation of chloroquine, without adequate evidence, is irresponsible and may cost lives without saving any. https://www.politico.com/amp/news/2020/04/06/trump-drug-coronavirus-hydroxychloroquine-170543 Unlike the fictitious homeopathic cure Forsythia, this is being hawked by the president.
Wuhan doctors treating coronavirus patients with chloroquine for the past few months say there's no clear evidence the drug works against COVID19, raising questions about a remedy some have touted as a potential cure. https://www.wsj.com/articles/chinese-doctors-at-coronavirus-hub-cast-doubt-on-chloroquine-as-cure-11586448660?redirect=amp#click=https://t.co/8N4iDcsRZn Via
@JNBPage @WSJ
@JNBPage @WSJ
Small Brazilian RCT of chloroquine for COVID19 (N=81) stopped early because treatment group developed concerning cardiac dysrhythmias. https://www.medrxiv.org/content/10.1101/2020.04.07.20056424v1
Observational study of US patients in VA system finds no benefit to chloroquine. N=368 patients were evaluated (HC, n=97; HC+AZ, n=113; no HC, n=158). Rates of death in the HC, HC+AZ, and no HC groups were 27.8%, 22.1%, 11.4%, respectively. https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf
FDA weighs in on use of chloroquine in COVID19. They are sensible. And unamused. https://www.nytimes.com/2020/04/24/health/fda-hydroxychloroquine-coronavirus.html#click=https://t.co/9FFd5QBDz2
Another small cohort study (N=90) suggests chloroquine does more harm than good in COVID19 cases. via @JAMACardio https://jamanetwork.com/journals/jamacardiology/fullarticle/2765631
This tweet about this topic, and the President’s reckless statement and Fox’s absurd and dangerous pandering to their crowd, was too good not to add to this thread. https://twitter.com/hoarsewisperer/status/1262488963639623680?s=21 https://twitter.com/TheRealHoarse/status/1262488963639623680
Three big studies dim hopes that hydroxychloroquine can treat or prevent COVID-19 https://www.sciencemag.org/news/2020/06/three-big-studies-dim-hopes-hydroxychloroquine-can-treat-or-prevent-covid-19
Fine, detailed twitter thread via @kakape as we approach the end of the story regarding the use of chloroquine for COVID19: https://twitter.com/kakape/status/1270662640499638272?s=20
More in vitro evidence via @CellPressNews that hydroxychloroquine is useless. It appears to inhibit trained immunity in vitro, which may not be beneficial for the antiviral innate immune response to SARS-CoV-2 infection in patients. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(20)30190-7?utm_campaign=Coronavirus%202020&utm_content=146304354&utm_medium=social&utm_source=twitter&hss_channel=tw-18477428
New RCT of hydroxychloroquine (HCQ) in @NEJM shows no effect in prevention. 2314 contacts of 672 COVID19 patients were identified; 1116 were assigned to HCQ & 1198 to usual care. COVID19 was similar (5.7% and 6.2%; risk ratio, 0.86 [95% CI, 0.52-1.42]). https://www.nejm.org/doi/full/10.1056/NEJMoa2021801#.X72F7LP9ia0.twitter
