Thread by @raphaels7, 1/ Rodent toxicology studies are probably *all* garbage. This has massive implications [...]

Raphael Sirtoli

raphaels7

1/ Rodent toxicology studies are probably *all* garbage. This has massive implications for the entire drug development industry. Why would I say something so outlandish?

@ChrisMasterjohn @ProfTimNoakes @DrEades @LDLskeptic2 @Evolutionistrue @DominicDAgosti2 @DaveKeto @robbwolf

2/ @BretWeinstein has exposed, circ 20yrs ago now, that the breeding protocols of the @jacksonlab have unwittingly selected for mice with incredibly long telomeres vs their wild-type counterparts

3/ This grants them ‘superpowers’ with regards to resisting toxicity but all but guarantees they’ll die of cancer (no free lunch in biology). No one knows if the @jacksonlab has acted on this information. It’s basically (nearly?) the sole provider of rodents for research

4/ @jacksonlab certainly spearheads best practices, ironically enough.

Podcast (big thanks to @EricRWeinstei) https://www.stitcher.com/podcast/kast-media-2/the-portal-2/e/66665404

Paper (predicted from first principles!) https://pubmed.ncbi.nlm.nih.gov/11909679/

For shame academia, for shame

The Reserve-Capacity Hypothesis: Evolutionary Origins and Modern Implications of the Trade-Off...

Antagonistic pleiotropy, the evolutionary theory of senescence, posits that age related somatic decline is the inevitable late-life by-product of adaptations that increase fitness in early life. That...

https://www.stitcher.com/podcast/kast-media-2/the-portal-2/e/66665404

@EricRWeinstein

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