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IL-6 is emerging as a key predictor of critical illness in #COVID19. A round-up of some recent (pre-review) data in this thread. 1/6
Herold et al. 40 #COVID19 patients, University Hospital Munich. Higher baseline IL-6 was strongly associated with subsequent need for mechanical ventilation (13 pt). (Associations also seen for Creatinine, LDH, CRP, WBC…). 2/6 https://www.medrxiv.org/content/10.1101/2020.04.01.20047381v1
Follow up IL-6 measurements were used to assess maximal IL-6 level for each patient. Maximal IL-6 was highly predictive of respiratory failure. For patients with IL-6 ≥80pg/ml, risk of respiratory failure was 92% (22 times higher than for patients with lower IL-6). 3/6
Liu et al: 69 severe, 11 non-severe #COVID19 patients, Wuhan China. IL-6 significantly increased in severe disease. IL-10 slightly increased. No difference in TNFa, IFNg, IL-2, IL-4. Severe patients had higher CRP, ESR, D-dimer, LDH, Ferritin. 4/6
https://www.medrxiv.org/content/10.1101/2020.03.01.20029769v2
https://www.medrxiv.org/content/10.1101/2020.03.01.20029769v2
Chen et al: 48 #COVID19 patients Wuhan, China, 17 critically ill of which 3 died. IL-6 significantly elevated in all critically ill patients. The 3 patients that died all had IL-6 levels >100pg/ml. 5/6 https://www.medrxiv.org/content/10.1101/2020.02.29.20029520v1
Wang et al: 11 #COVID19 patients with ARDS, Guangzhou Medical University, China. All had significantly elevated IL-6. 6/6 https://www.medrxiv.org/content/10.1101/2020.02.26.20026989v1
