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Why are children safe?
"Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (O2 sequestering) proteins of anaerobic bacteria (Prevotella, et al)" https://osf.io/vzmf3/ ">https://osf.io/vzmf3/&qu...
Why are children safe?
"Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (O2 sequestering) proteins of anaerobic bacteria (Prevotella, et al)" https://osf.io/vzmf3/ ">https://osf.io/vzmf3/&qu...
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Not all bacteria can degrade hemoglobin. https://www.sciencedirect.com/science/article/abs/pii/S1075996406000709">https://www.sciencedirect.com/science/a...
Not all bacteria can degrade hemoglobin. https://www.sciencedirect.com/science/article/abs/pii/S1075996406000709">https://www.sciencedirect.com/science/a...
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Once hemoglobin is degraded, it also has heme-binding proteins that can sequester the heme (where the iron binds and removes oxygen)
So you feel breathless. And ventilators are required. https://pubmed.ncbi.nlm.nih.gov/31899475/ ">https://pubmed.ncbi.nlm.nih.gov/31899475/...
Once hemoglobin is degraded, it also has heme-binding proteins that can sequester the heme (where the iron binds and removes oxygen)
So you feel breathless. And ventilators are required. https://pubmed.ncbi.nlm.nih.gov/31899475/ ">https://pubmed.ncbi.nlm.nih.gov/31899475/...
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What about children?
The type of hemoglobin changes through our life cyle.
HbF (fetal hemoglobin) is predominant in a new-born, and comes down within a year to our adult life percentage (less than 1%)
https://www.uptodate.com/contents/fetal-hemoglobin-hemoglobin-f-in-health-and-disease
(not">https://www.uptodate.com/contents/... for everyone - but hold that thought)
What about children?
The type of hemoglobin changes through our life cyle.
HbF (fetal hemoglobin) is predominant in a new-born, and comes down within a year to our adult life percentage (less than 1%)
https://www.uptodate.com/contents/fetal-hemoglobin-hemoglobin-f-in-health-and-disease
(not">https://www.uptodate.com/contents/... for everyone - but hold that thought)
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Now, fetal hemoglobin binds oxygen much stronger.
So, maybe Prevotella cant break it (HbF) to access the heme.
https://en.wikipedia.org/wiki/Fetal_hemoglobin
"Thus,">https://en.wikipedia.org/wiki/Feta... the key feature that allows hemoglobin F to bind more strongly to oxygen is by having γ subunits (instead of β, for example)"
Now, fetal hemoglobin binds oxygen much stronger.
So, maybe Prevotella cant break it (HbF) to access the heme.
https://en.wikipedia.org/wiki/Fetal_hemoglobin
"Thus,">https://en.wikipedia.org/wiki/Feta... the key feature that allows hemoglobin F to bind more strongly to oxygen is by having γ subunits (instead of β, for example)"
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Why is #Covid19 low in malaria endemic regions?
There are many possibilities (one of that is the newly proposed CD147 entry protein - which is the same in malaria).
But also that fetal hemoglobin is high in people with sickle-cell sickness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831961/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Why is #Covid19 low in malaria endemic regions?
There are many possibilities (one of that is the newly proposed CD147 entry protein - which is the same in malaria).
But also that fetal hemoglobin is high in people with sickle-cell sickness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831961/">https://www.ncbi.nlm.nih.gov/pmc/artic...
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"The degree of HbF persistence varies greatly between adult individuals and this variability is largely genetically controlled" https://pubmed.ncbi.nlm.nih.gov/19344402/ ">https://pubmed.ncbi.nlm.nih.gov/19344402/...
"The degree of HbF persistence varies greatly between adult individuals and this variability is largely genetically controlled" https://pubmed.ncbi.nlm.nih.gov/19344402/ ">https://pubmed.ncbi.nlm.nih.gov/19344402/...
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This is substantiated by data from metagenomes.
https://sanchakblog.wordpress.com/2020/04/06/data-heme-binding-proteins-from-bacteria-in-patients-from-two-studies/
Interestingly,">https://sanchakblog.wordpress.com/2020/04/0... no heme binding protein was found in 5 patients in their early stage -
indicating the bacteria turns on expression sensing something as the disease progresses – maybe oxygen?
This is substantiated by data from metagenomes.
https://sanchakblog.wordpress.com/2020/04/06/data-heme-binding-proteins-from-bacteria-in-patients-from-two-studies/
Interestingly,">https://sanchakblog.wordpress.com/2020/04/0... no heme binding protein was found in 5 patients in their early stage -
indicating the bacteria turns on expression sensing something as the disease progresses – maybe oxygen?
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Why does it still hold true in slightly elder children... https://twitter.com/sanchak74/status/1247740706501738498">https://twitter.com/sanchak74...
Why does it still hold true in slightly elder children... https://twitter.com/sanchak74/status/1247740706501738498">https://twitter.com/sanchak74...
