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1/
Why are children safe?
"Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (O2 sequestering) proteins of anaerobic bacteria (Prevotella, et al)" https://osf.io/vzmf3/
Why are children safe?
"Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (O2 sequestering) proteins of anaerobic bacteria (Prevotella, et al)" https://osf.io/vzmf3/
2/
Not all bacteria can degrade hemoglobin. https://www.sciencedirect.com/science/article/abs/pii/S1075996406000709
Not all bacteria can degrade hemoglobin. https://www.sciencedirect.com/science/article/abs/pii/S1075996406000709
3/
Once hemoglobin is degraded, it also has heme-binding proteins that can sequester the heme (where the iron binds and removes oxygen)
So you feel breathless. And ventilators are required. https://pubmed.ncbi.nlm.nih.gov/31899475/
Once hemoglobin is degraded, it also has heme-binding proteins that can sequester the heme (where the iron binds and removes oxygen)
So you feel breathless. And ventilators are required. https://pubmed.ncbi.nlm.nih.gov/31899475/
4/
What about children?
The type of hemoglobin changes through our life cyle.
HbF (fetal hemoglobin) is predominant in a new-born, and comes down within a year to our adult life percentage (less than 1%)
https://www.uptodate.com/contents/fetal-hemoglobin-hemoglobin-f-in-health-and-disease
(not for everyone - but hold that thought)
What about children?
The type of hemoglobin changes through our life cyle.
HbF (fetal hemoglobin) is predominant in a new-born, and comes down within a year to our adult life percentage (less than 1%)
https://www.uptodate.com/contents/fetal-hemoglobin-hemoglobin-f-in-health-and-disease
(not for everyone - but hold that thought)
5/
Now, fetal hemoglobin binds oxygen much stronger.
So, maybe Prevotella cant break it (HbF) to access the heme.
https://en.wikipedia.org/wiki/Fetal_hemoglobin
"Thus, the key feature that allows hemoglobin F to bind more strongly to oxygen is by having γ subunits (instead of β, for example)"
Now, fetal hemoglobin binds oxygen much stronger.
So, maybe Prevotella cant break it (HbF) to access the heme.
https://en.wikipedia.org/wiki/Fetal_hemoglobin
"Thus, the key feature that allows hemoglobin F to bind more strongly to oxygen is by having γ subunits (instead of β, for example)"
6/
Why is #Covid19 low in malaria endemic regions?
There are many possibilities (one of that is the newly proposed CD147 entry protein - which is the same in malaria).
But also that fetal hemoglobin is high in people with sickle-cell sickness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831961/
Why is #Covid19 low in malaria endemic regions?
There are many possibilities (one of that is the newly proposed CD147 entry protein - which is the same in malaria).
But also that fetal hemoglobin is high in people with sickle-cell sickness https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831961/
7/
"The degree of HbF persistence varies greatly between adult individuals and this variability is largely genetically controlled" https://pubmed.ncbi.nlm.nih.gov/19344402/
"The degree of HbF persistence varies greatly between adult individuals and this variability is largely genetically controlled" https://pubmed.ncbi.nlm.nih.gov/19344402/
8/
This is substantiated by data from metagenomes.
https://sanchakblog.wordpress.com/2020/04/06/data-heme-binding-proteins-from-bacteria-in-patients-from-two-studies/
Interestingly, no heme binding protein was found in 5 patients in their early stage -
indicating the bacteria turns on expression sensing something as the disease progresses – maybe oxygen?
This is substantiated by data from metagenomes.
https://sanchakblog.wordpress.com/2020/04/06/data-heme-binding-proteins-from-bacteria-in-patients-from-two-studies/
Interestingly, no heme binding protein was found in 5 patients in their early stage -
indicating the bacteria turns on expression sensing something as the disease progresses – maybe oxygen?
9/
Why does it still hold true in slightly elder children... https://twitter.com/sanchak74/status/1247740706501738498
Why does it still hold true in slightly elder children... https://twitter.com/sanchak74/status/1247740706501738498
