Hermida's group long-term study: bedtime dosing of #hypertension meds cuts composite #CardiovascularEvents by 50%

I usually tell folks to take their diuretic in the morning so they don't get nocturia interrupting their sleep - what to do? #nephtwitter

https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz754/5602478#.XoYTViN-S3s.twitter

For several years I've been favoring the "spread BP meds out morning and evening" approach after the paper by Minutolo et al. in 2007
Albeit this was a cross-over trial (not RCT) and didn't look at hard CV outcomes...