Hydroxychloroquine works by activating the innate immune system signaling pathways of IFN-β, AP-1, & NFκB.

These signaling pathways help inhibit the anti-inflammatory environment exuded by the virus to evade immune detection, and induce apoptosis in virus infected cells.

IFN-β has been shown to reduce viral replication of COVID-19 by 99% in vitro, which is one of the signaling pathways Hydroxychloroquine activates.

HCQ has also been shown to increase extra-cellular ROS (reactive oxygen species) production, a byproduct of mitochondrial processes and also a cellular response to a viral infection.

ROS is generated by the immune system to act as a potent destroyer of invading pathogens.

It some studies, it was shown that HCQ inhibited HIV-1 replication by > 75%. It was also shown to inhibit replication of HPV, HSV-1+2, Zika, DENV, & COVID-19.

Based on the pharmacology and medical literature, this drug, along with Azithromycin, will be very effective at treating COVID-19, likely resulting in full viral eradication.