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c1/03/26/20 @Bob_Wachter reports several new COVID-19 Conferences at @UCSF: https://twitter.com/Bob_Wachter/status/1243689292293009408
c2/This thread annotates @annieluet's talk from
"UCSF research response to Covid" Research Town Hall
All talks worth watching, but fairly technical.
https://research.ucsf.edu/covid-19-campus-wide-research-ucsf-making-impact
That page has other good COVID resources, @UCSF is very open with quick updates, status, research.
"UCSF research response to Covid" Research Town Hall
All talks worth watching, but fairly technical.
https://research.ucsf.edu/covid-19-campus-wide-research-ucsf-making-impact
That page has other good COVID resources, @UCSF is very open with quick updates, status, research.
c3/Clinical trials for COVID-19 - Professor Annie Luetkemeyer @annieluet
https://vimeo.com/401444481/5b7c5dc4f4 11:40 length
https://vimeo.com/401444481/5b7c5dc4f4 11:40 length
c4/00:35 Current UCSF COVID Clinical Trials
Rapidly evolving situation.
RCT = Randomized Controlled Trial
ARDS = Acute Respiratory Distress Syndrome (i.e, already very sick, on or will be on ventilator)
Rapidly evolving situation.
RCT = Randomized Controlled Trial
ARDS = Acute Respiratory Distress Syndrome (i.e, already very sick, on or will be on ventilator)
c5/01:54 Remdesivir (currently enrolling)
Broad anti-viral activity in-vitro, vs SARS, MERS, Ebola
Does this do anything to help COVID patients?
5 RCTs enrolling.
Broad anti-viral activity in-vitro, vs SARS, MERS, Ebola
Does this do anything to help COVID patients?
5 RCTs enrolling.
c6/03:18 NIH Multicenter RCT of Remdesivir
IV formulation, no oral available now
Intervention is blinded (so patient & doctors don’t know)
They are evaluating other endpoints (ways to score results).
IV formulation, no oral available now
Intervention is blinded (so patient & doctors don’t know)
They are evaluating other endpoints (ways to score results).
c7/(This is the description of trial in official database.
NIAID is the part of NIH whose Director is Dr. Anthony Fauci, recently well-known to public.
This is what a real trial looks like, worth studying.
Structure allows for change over time.
https://clinicaltrials.gov/ct2/show/NCT04280705?term=remdesivir&cntry=US&draw=2&rank=4
NIAID is the part of NIH whose Director is Dr. Anthony Fauci, recently well-known to public.
This is what a real trial looks like, worth studying.
Structure allows for change over time.
https://clinicaltrials.gov/ct2/show/NCT04280705?term=remdesivir&cntry=US&draw=2&rank=4
c8/05:47 NIH Multicenter RCT of Remdesivir
Study has picked up patients, expect fully enrolled soon.
Very quick: from getting documents until start = 9 days(!)
Study has picked up patients, expect fully enrolled soon.
Very quick: from getting documents until start = 9 days(!)
c9/07:55 Adaptive Content
Additional drugs might get incorporated later.
Drug Y: active discussion, important that they can quickly incorporate.
(All this is set up to happen at unusual speed, people are trying very hard.)
Additional drugs might get incorporated later.
Drug Y: active discussion, important that they can quickly incorporate.
(All this is set up to happen at unusual speed, people are trying very hard.)
c10/08:53 Coming soon
Hoping will enroll soon.
Much controversy around hydroxycholoroquine (HCQ), and whether it works, and if it will work, need to optimize dose.
ASTER study for critically-ill ARDS patients, not just COVID.
Hoping will enroll soon.
Much controversy around hydroxycholoroquine (HCQ), and whether it works, and if it will work, need to optimize dose.
ASTER study for critically-ill ARDS patients, not just COVID.
