With widespread adoption of single-cell-omics technologies, developmental biologists are increasingly relying on the use of “gene expression trajectories” to study cell differentiation. What is the difference between a trajectory and a lineage? (1/4)

What should we conclude when trajectories and lineage tracing offer conflicting views of cellular history- as they so often do? In this review, we discuss these questions along with an emerging class of molecular approaches that integrate simultaneous omics and... (2/4)

lineage measurements in single cells. These integrative approaches resolve conflicts and are helping us to better understand non-tree like differentiation trajectories, to localize fate boundaries on state landscapes, and to extract consensus trends from large ensembles... (3/4)

of lineage measurements. Please RT and send any questions our way! The article will have no pay wall for the next month, so you can add it to your COVID19 lockdown reading list. Please everyone, stay healthy and stay home! (4/4)