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Social-distancing guidelines to stay 6 feet from others may be woefully inadequate, MIT associate professor Lydia Bourouiba warns — saying the coronavirus can travel 27 feet and linger for hours.
https://jamanetwork.com/journals/jama/fullarticle/2763852?resultClick=1
https://jamanetwork.com/journals/jama/fullarticle/2763852?resultClick=1
"Currently available research supports the possibility that [coronavirus] could be spread via bioaerosols generated directly by patients' exhalation," https://www.cnn.com/2020/04/02/health/aerosol-coronavirus-spread-white-house-letter/index.html
As per following studiy, 15 of 102 (14.7%) cats found to b having anti #SARSCoV2 in their sera in Wuhan during the outbreak, indicating that cats do get infected with #SARSCoV2 https://www.biorxiv.org/content/10.1101/2020.04.01.021196v1
“The cats we used in this study were [...] were highly susceptible to #SARSCoV2 which replicated efficiently and transmitted to naïve cats,”
Meaning cats are not only very susceptible to #SARSCoV2 but cat to cat transmission is rampant.
https://www.biorxiv.org/content/10.1101/2020.03.30.015347v1.full.pdf
Meaning cats are not only very susceptible to #SARSCoV2 but cat to cat transmission is rampant.
https://www.biorxiv.org/content/10.1101/2020.03.30.015347v1.full.pdf
"Pigs, ferrets, cats, orangutans, monkeys, some species of bats & humans have similar affinity for SARS-CoV-2 based on structural similarity of their ACE2 receptors"
Cats &(at least couple of) dogs have got infection from human but reverse isn't recorded https://www.the-scientist.com/news-opinion/which-species-transmit-covid-19-to-humans-were-still-not-sure-67272
Cats &(at least couple of) dogs have got infection from human but reverse isn't recorded https://www.the-scientist.com/news-opinion/which-species-transmit-covid-19-to-humans-were-still-not-sure-67272
Interestingly, the term #SARSCoV2 has been used before (in 2006) in naming a primer
@WHO
To reduce costs and simplify multivirus detection, RNA splices of HCV, HIV-1, SARS-CoV1 & SARS-CoV2 were merged into a chimera- armored RNA production vector pAR-1 https://academic.oup.com/clinchem/article/52/7/1446/5627058
@WHO
To reduce costs and simplify multivirus detection, RNA splices of HCV, HIV-1, SARS-CoV1 & SARS-CoV2 were merged into a chimera- armored RNA production vector pAR-1 https://academic.oup.com/clinchem/article/52/7/1446/5627058
A Tiger (cat family) has tested +ve in US
1) 1st known animal to test positive for #SARSCoV2 in the US
2) Bronx Zoo closed to public in mid-Mar & tiger that tested positive began showing symptoms on 27 Mar
3) 6 feet anyone?
Thnx @charliechancat https://www.axios.com/tiger-coronavirus-bronx-zoo-4582f9db-9c71-45b5-a7b8-df9886b4256e.html?utm_source=twitter&utm_medium=social&utm_campaign=organic&utm_content=1100
1) 1st known animal to test positive for #SARSCoV2 in the US
2) Bronx Zoo closed to public in mid-Mar & tiger that tested positive began showing symptoms on 27 Mar
3) 6 feet anyone?
Thnx @charliechancat https://www.axios.com/tiger-coronavirus-bronx-zoo-4582f9db-9c71-45b5-a7b8-df9886b4256e.html?utm_source=twitter&utm_medium=social&utm_campaign=organic&utm_content=1100
COVID-19 Outbreak Associated with Air Conditioning in Restaurant
“droplet transmission was prompted by air-conditioned ventilation. The key factor for infection was the direction of the airflow.”
But technically, it's still aerosol borne & NOT airborne!
https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article
“droplet transmission was prompted by air-conditioned ventilation. The key factor for infection was the direction of the airflow.”
But technically, it's still aerosol borne & NOT airborne!
https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article
Each carrier is infecting 5.7 people on average (R0) https://www.msn.com/en-my/news/world/chinas-initial-coronavirus-outbreak-in-wuhan-spread-twice-as-fast-as-we-thought-new-study-suggests/ar-BB12DO19?srcref=rss
Achieving so-called herd immunity would need at least 82% (not 60% as previously thought) of people to be immune (by infection or vaccination) to stop the contagion https://www.scmp.com/week-asia/explained/article/3075754/what-herd-immunity-and-can-it-stop-coronavirus
Aligning a few posts on eyebrow raising uniqueness of this virus..
"Aix-Marsellie University in France found that after heating the virus to 60C for an hour it was still able to replicate" https://twitter.com/dr_gsharma/status/1250009726340882432?s=20
"Aix-Marsellie University in France found that after heating the virus to 60C for an hour it was still able to replicate" https://twitter.com/dr_gsharma/status/1250009726340882432?s=20
Playing Hide-&-Seek with Immune system...this is how long term disease progression will b...realistic chance of reinfection or relapse!
https://twitter.com/dr_gsharma/status/1249243752058650628?s=20
https://twitter.com/dr_gsharma/status/1249243752058650628?s=20
Very interesting article on mechanism of Chloroquine on #SARSCoV2
& its Pathogenesis
It changes everything!
1 Pneumonia/ARDS is NOT a critical factor
2 Ventillators may b wrong strategy
3 Immune hemolysis releasing Fe ion is central to Pathogenesis https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
& its Pathogenesis
It changes everything!
1 Pneumonia/ARDS is NOT a critical factor
2 Ventillators may b wrong strategy
3 Immune hemolysis releasing Fe ion is central to Pathogenesis https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
4 Chloroquine could prevent ORF1ab, ORF3a & ORF10 to attack heme to form porphyrin & inhibit binding of ORF8 & surface glycoproteins to porphyrins to certain extent
5 Favipiravir could inhibit envelope protein &ORF7a protein bind to porphyrinprevent virus from entering host cell
5 Favipiravir could inhibit envelope protein &ORF7a protein bind to porphyrinprevent virus from entering host cell
Summary
Virus 1st infected cells with ACE2 receptors, including immune cells
Immune cells produced Ab
Antibodies & red blood cells generated immune hemolysis
Hb was infected & then attacked
Virus captured porphyrin & inhibited heme metabolism resulting hypoxia & heme toxicity
Virus 1st infected cells with ACE2 receptors, including immune cells
Immune cells produced Ab
Antibodies & red blood cells generated immune hemolysis
Hb was infected & then attacked
Virus captured porphyrin & inhibited heme metabolism resulting hypoxia & heme toxicity
More on atypical HIV like behaviour of #SARSCoV2 https://twitter.com/dr_gsharma/status/1250805750340874242?s=19
Why home quarantine may very well b bad idea?
Lesson to learn from docked ships...why they behave like culture media...
Simple answer: They don't have negative pressure rooms & #SARSCoV2 remains viable for 12+ hrs in aerosols https://twitter.com/linseymarr/status/1252015438638329857?s=19
Lesson to learn from docked ships...why they behave like culture media...
Simple answer: They don't have negative pressure rooms & #SARSCoV2 remains viable for 12+ hrs in aerosols https://twitter.com/linseymarr/status/1252015438638329857?s=19
1) 44% of secondary cases were infected during index cases’ presymptomatic stage.
2) NO difference between amount of shedding & various factors such as severity, age, sex...
3) >90% of the contacts need to b traced & isolated to make strategy successful. https://www.nature.com/articles/s41591-020-0869-5
2) NO difference between amount of shedding & various factors such as severity, age, sex...
3) >90% of the contacts need to b traced & isolated to make strategy successful. https://www.nature.com/articles/s41591-020-0869-5
