Social-distancing guidelines to stay 6 feet from others may be woefully inadequate, MIT associate professor Lydia Bourouiba warns — saying the coronavirus can travel 27 feet and linger for hours.
https://abs.twimg.com/emoji/v2/... draggable="false" alt="😳" title="Flushed face" aria-label="Emoji: Flushed face"> https://jamanetwork.com/journals/jama/fullarticle/2763852?resultClick=1">https://jamanetwork.com/journals/...
“The cats we used in this study were [...] were highly susceptible to #SARSCoV2 which replicated efficiently and transmitted to naïve cats,”

Meaning cats are not only very susceptible to #SARSCoV2 but cat to cat transmission is rampant.
https://www.biorxiv.org/content/10.1101/2020.03.30.015347v1.full.pdf">https://www.biorxiv.org/content/1...
"Pigs, ferrets, cats, orangutans, monkeys, some species of bats & humans have similar affinity for SARS-CoV-2 based on structural similarity of their ACE2 receptors"

Cats &(at least couple of) dogs have got infection from human but reverse isn& #39;t recorded https://www.the-scientist.com/news-opinion/which-species-transmit-covid-19-to-humans-were-still-not-sure-67272">https://www.the-scientist.com/news-opin...
Interestingly, the term #SARSCoV2 has been used before (in 2006) in naming a primer
@WHO

To reduce costs and simplify multivirus detection, RNA splices of HCV, HIV-1, SARS-CoV1 & SARS-CoV2 were merged into a chimera- armored RNA production vector pAR-1 https://academic.oup.com/clinchem/article/52/7/1446/5627058">https://academic.oup.com/clinchem/...
A Tiger (cat family) has tested +ve in US

1) 1st known animal to test positive for #SARSCoV2 in the US

2) Bronx Zoo closed to public in mid-Mar & tiger that tested positive began showing symptoms on 27 Mar

3) 6 feet anyone? https://abs.twimg.com/emoji/v2/... draggable="false" alt="🙄" title="Face with rolling eyes" aria-label="Emoji: Face with rolling eyes">

Thnx @charliechancat https://www.axios.com/tiger-coronavirus-bronx-zoo-4582f9db-9c71-45b5-a7b8-df9886b4256e.html?utm_source=twitter&utm_medium=social&utm_campaign=organic&utm_content=1100">https://www.axios.com/tiger-cor...
COVID-19 Outbreak Associated with Air Conditioning in Restaurant
“droplet transmission was prompted by air-conditioned ventilation. The key factor for infection was the direction of the airflow.”

But technically, it& #39;s still aerosol borne & NOT airborne!
https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article">https://wwwnc.cdc.gov/eid/artic...
Aligning a few posts on eyebrow raising uniqueness of this virus..

"Aix-Marsellie University in France found that after heating the virus to 60C for an hour it was still able to replicate" https://twitter.com/dr_gsharma/status/1250009726340882432?s=20">https://twitter.com/dr_gsharm...
Playing Hide-&-Seek with Immune system...this is how long term disease progression will b...realistic chance of reinfection or relapse!
https://twitter.com/dr_gsharma/status/1249243752058650628?s=20">https://twitter.com/dr_gsharm...
4 Chloroquine could prevent ORF1ab, ORF3a & ORF10 to attack heme to form porphyrin & inhibit binding of ORF8 & surface glycoproteins to porphyrins to certain extent
5 Favipiravir could inhibit envelope protein &ORF7a protein bind to porphyrinprevent virus from entering host cell
Summary
Virus 1st infected cells with ACE2 receptors, including immune cells

Immune cells produced Ab

Antibodies & red blood cells generated immune hemolysis

Hb was infected & then attacked

Virus captured porphyrin & inhibited heme metabolism resulting hypoxia & heme toxicity
More on atypical HIV like behaviour of #SARSCoV2 https://twitter.com/dr_gsharma/status/1250805750340874242?s=19">https://twitter.com/dr_gsharm...
Why home quarantine may very well b bad idea?
Lesson to learn from docked ships...why they behave like culture media...

Simple answer: They don& #39;t have negative pressure rooms & #SARSCoV2 remains viable for 12+ hrs in aerosols https://twitter.com/linseymarr/status/1252015438638329857?s=19">https://twitter.com/linseymar...
1) 44% of secondary cases were infected during index cases’ presymptomatic stage.
2) NO difference between amount of shedding & various factors such as severity, age, sex...
3) >90% of the contacts need to b traced & isolated to make strategy successful. https://www.nature.com/articles/s41591-020-0869-5">https://www.nature.com/articles/...
You can follow @dr_gsharma.
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