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Here is a comprehensive study on the Vaccine(s) that are being tested/studied for COVID-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094941/
As SARS-CoV-2 enters human body through ACE-2 (Angotensin coverting enzyme 2) receptors, Angiotensin Blockers are viewed as potential therapy. @Dereklowe writes why it is incredibly complicated. https://blogs.sciencemag.org/pipeline/archives/2020/03/17/angiotensin-and-the-coronavirus
Here is a RNAseq analysis of ACE-2 expression in different organs of human body. High ACE-2 expression in an organ (protein,which is not necessarily the same as RNA) means increased potential risks of Organ failure because of COVID-19.
Earlier today, found this ( https://www.biorxiv.org/content/10.1101/2020.03.28.013672v1) pre-print from @JSheltzer that correlates smoking with increased ACE2 expression and thus increase risk from COVID-19. Similarly, diabetes, some anti-hypertension medicines are also known to drive ACE-2 expression.
Human ACE-2 Protein is 99% similar to Gorilla ACE-2 protein. This virus could potentially wipe out the Gorilla population(s). (P.S. I/we do not know about Gorilla immunity to the virus, neither have i done binding studies.)
If you are interested in how this virus (coronavirus) works in molecular level, like i am, here is a pretty good lecture
The virus has multi-pronged molecular mechanism that works to evade interferon signaling (ie. Body recognizing virus is there) before it reaches its titer. This is what makes it dangerous.
The virus wasn't made in a lab, herr isa comprehensive study. https://www.sciencenews.org/article/coronavirus-covid-19-not-human-made-lab-genetic-analysis-nature
