Thread by @PM_Travel_Tours, People who have recovered from Covid-19 have antibodies in their blood plasma [...]

People who have recovered from Covid-19 have antibodies in their blood plasma that maintain a defence against the infection.

The aim of this move is to identify those who are “hyperimmune” to the virus and invite them to donate blood for the treatment. https://www.theguardian.com/science/2020/mar/29/coronavirus-survivors-blood-plasma-could-be-used-to-fight-infection">https://www.theguardian.com/science/2...

Coronavirus survivors’ blood plasma could be used to fight infection

Patients, carers and NHS staff could receive experimental antibody treatment

https://www.theguardian.com/science/2020/mar/29/coronavirus-survivors-blood-plasma-could-be-used-to-fight-infection

What exactly do the #COVID19 tests do? Basically, from the sample taken [usually throat swab], they use the Reverse Transcription real-time Polymerase Chain Reaction to:
1. transcribe RNA to DNA
2. Make copies and amplify target gene [mostly E or N]
3. Confirmatory - ORF1b gene

If you go through the thread, you will notice that there is a lot of intelligent methodology being applied to what is inherently a complex structure.The details do boggle the mind.

It is easier to just "believe" and bang thalis, the root of superstition being ignorance.

That is the level of detailing Science has to undertake. Zeroing in on the precise markers within a 30 Kilobase genome length, to isolate what defines SARS-COV-2.

But yeah! Bang thalis since all this is hocus-pocus [yes, i have heard such "science-is-a-belief accusations too]

As that Poet once said [of Newton i think],the beauty of the rainbow was destroyed by reducing it to mere prismatic colors.

Keats!

Science makes stuff so much more beautiful.The aesthetic appreciation remains,appreciation for the beauty of mechanisms that lie beneath gets added

Individuals and cults that ache for power [political/religious] usually hate science because the key to power is fear [and hence artificial, divine/temporal solace-laced pills], and the foundational element to fear is ignorance.

Keep people ignorant. Control them easily.

Like i said somewhere abv,the SARS-COV-2 has not mutated much, which is good news.Mutations make the immune system less effective in dealing with it.

Here are the specific deletions fm a study. 3 deletions in key regions,involving <25 nucleotides each, 90 other across the genome

For those who are interested, link to full paper here. Primarily around studies concerning mutations in SARS-COV-2
https://www.sciencedirect.com/science/article/pii/S1567134820300915

Hint:
Nucleotide">https://www.sciencedirect.com/science/a... codes for amino acid
Gene codes for Protein
Genome is the entire DNA strand.
Deletion is a form of mutation [see abv tweet]

Genetic diversity and evolution of SARS-CoV-2

COVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health Organization declared the SARS-CoV-2 outbreak …

https://www.sciencedirect.com/science/article/pii/S1567134820300915

The 16 supercomputers in the network represent 330 petaflops, 775,000 CPU cores, and 34,000 graphics processing units. As a comparison, it would take nearly 100,000 new MacBook Pros working at peak performance to match the results of the supercomputers. https://www.the-scientist.com/news-opinion/covid-19-vaccine-developers-gain-enhanced-access-to-supercomputers-67342">https://www.the-scientist.com/news-opin...

COVID-19 Vaccine Developers Gain Enhanced Access to Supercomputers

Federal agencies, academic institutions, and industrial partners are joining forces to combat COVID-19 using artificial intelligence.

https://www.the-scientist.com/news-opinion/covid-19-vaccine-developers-gain-enhanced-access-to-supercomputers-67342

Useful. Very useful. I had raised the issue of antibodies in some tweet way up the thread i think.

Anyway, this is great news. Antibody tests will be crucial for decisions around the reintroduction of workforce and people into the mainstream, so to say. https://www.startribune.com/u-mayo-ready-covid-19-antibody-tests-in-minnesota/569233992/">https://www.startribune.com/u-mayo-re...

University of Minnesota, Mayo Clinic ready COVID-19 antibody tests in Minnesota

The University of Minnesota and Mayo Clinic are hoping antibody test could help determine who is no longer a threat.

https://www.startribune.com/u-mayo-ready-covid-19-antibody-tests-in-minnesota/569233992/

The antibody test is primarily a serology test and serves as useful a purpose as the RT-rtPCR that is being used to detect people with infections. The former checks for antibodies that the body came up with to counter the SARS-COV-2.
https://www.biomedomics.com/products/infectious-disease/covid-19-rt/">https://www.biomedomics.com/products/...

Not peer reviewed yet. But fascinating how quickly the world of Science hs bn mvng on SARS-COV-2

Compare that to how fast the State & Media hv moved to spread fear, panic and ignorance.

"A serological assay to detect SARS-CoV-2 seroconversion in humans"
https://www.medrxiv.org/content/10.1101/2020.03.17.20037713v1.full.pdf">https://www.medrxiv.org/content/1...

More on the topic of antibodies.
Germany is being very proactive I must say. Come to think of it, India probably needs this test more - given the ease of administration [relatively] and scalability. https://www.telegraph.co.uk/news/2020/03/29/germany-will-issue-coronavirus-antibody-certificates-allow-quarantined/">https://www.telegraph.co.uk/news/2020...

Germany will issue coronavirus antibody certificates to allow quarantined to re-enter society

Researchers to test thousands for immunity as Berlin plans exit strategy for pandemic lock down

https://www.telegraph.co.uk/news/2020/03/29/germany-will-issue-coronavirus-antibody-certificates-allow-quarantined/

So basically,while Germany is already planning an exit strategy from #Covid19, India is still busy playing medieval games on religion led from the front by its politicians, opinion-shapers and low IQ crowd in the Media [the lowest being TV News Anchors] as well as on Social Media

Your body, a wonderland:

Antibody-secreting cells (ASCs)
Follicular helper T cells (TFH cells)
CD4+ T cells, CD8+ T cells
Immunoglobulin M (IgM), IgG antibodies

Stress can dial this down quite a bit. Stay in good cheer.
#Immune Response to #SARS_COV_2 #MOESM2">https://www.nature.com/articles/s41591-020-0819-2 #MOESM2">https://www.nature.com/articles/...

Breadth of concomitant immune responses prior to patient recovery: a c

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

https://www.nature.com/articles/s41591-020-0819-2#MOESM2

This goes here since stress response, glucocorticoids, immune response to pathogens including SARS-COV-2] are all inter-connected.

See above tweet for body& #39;s immune response to the virus in question. https://twitter.com/PM_Travel_Tours/status/1245232670331654144?s=20">https://twitter.com/PM_Travel...

https://twitter.com/PM_Travel_Tours/status/1245232670331654144?s=20

Simply using the correlation between age and fatality rate is not indicative of causation. There are other key variables:
ACE 2 receptors
ATL proteins + strength of binding
Relevant gene expression
Relevant immunity molecules
Glucocorticoids
Co-morbidities https://www.mercurynews.com/2020/04/01/coronavirus-how-sick-will-you-get/">https://www.mercurynews.com/2020/04/0...

Coronavirus: How sick will you get?

Together, a Palo Alto couple fell ill. He recovered quickly. She didn’t. Why?

https://www.mercurynews.com/2020/04/01/coronavirus-how-sick-will-you-get/

And some more good news.
https://jamanetwork.com/journals/jama/fullarticle/2763983?resultClick=1
Antibody">https://jamanetwork.com/journals/... rich Plasma fm those who recovered & tested negative,being used to treat critically ill.More RCTs needed, i believe there are some currently underway. Body& #39;s natural immunity system - never under-estimate what it can do.

Treatment of Critically Ill Patients With COVID-19 With Convalescent Plasma

This case series describes clinical outcomes in 5 Chinese patients with laboratory-confirmed COVID-19, ARDS, and high viral loads despite antiviral treatment who were given human plasma with SARS-C...

https://jamanetwork.com/journals/jama/fullarticle/2763983?resultClick=1

Meanwhile, in India,THIS is the progress that Medical Science is making.This is a Govt. handle which is peddling a curious mix of parapsychology, pseudoscience and unverifiable claims. Collective consciousness can dislodge corona virus from ACE2 receptors!
https://twitter.com/mygovindia/status/1245932029327192065?s=20">https://twitter.com/mygovindi...

https://twitter.com/mygovindia/status/1245932029327192065?s=20

This is the video that @mygovindia tweeted and then deleted.

It is an important milestone in the descent into decay of a Government, so inserting it here - a sharp contrast to the tone of the entire thread. https://twitter.com/karishmau/status/1245950575075708928?s=20">https://twitter.com/karishmau...

https://twitter.com/karishmau/status/1245950575075708928?s=20

University of Pittsburgh : potential vaccine against SARS-CoV-2. When tested in mice, the vaccine, delivered through a fingertip-sized patch, produces antibodies specific to SARS-CoV-2 at quantities thought to be sufficient for neutralizing the virus.
https://www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(20)30118-3.pdf">https://www.thelancet.com/pdfs/jour...

If the Lancet paper shared in tweet above seems too heavy, you could go through a summary of that paper here. https://neurosciencenews.com/covid-19-vaccine-promise-16062/amp/">https://neurosciencenews.com/covid-19-...

COVID-19 vaccine candidate shows promise in first peer-reviewed research - Neuroscience News

A new COVID-19 vaccine produces antibodies specific to SARS-CoV-2 at quantities believed sufficient for neutralizing the virus, a mouse model study reveals. The new vaccine using an innovative...

https://neurosciencenews.com/covid-19-vaccine-promise-16062/amp/

"Favipiravir works by inhibiting the replication of viral genes within infected cells, thereby mitigating the virus’s ability to spread from one cell to another."

Japan joins the hunt for covid19 treatment. https://www.wired.com/story/japan-is-racing-to-test-a-drug-to-treat-covid-19/?mbid=social_twitter&utm_brand=wired&utm_campaign=wired&utm_medium=social&utm_social-type=owned&utm_source=twitter">https://www.wired.com/story/jap...

Japan Is Racing to Test a Drug to Treat Covid-19

Based on a compound discovered in 1998, the antiviral Favipiravir is already being used in Japan and Turkey. Its maker? A subsidiary of Fujifilm.

https://www.wired.com/story/japan-is-racing-to-test-a-drug-to-treat-covid-19/?mbid=social_twitter&utm_brand=wired&utm_campaign=wired&utm_medium=social&utm_social-type=owned&utm_source=twitter

Finally!!! Rapid antibody tests.

This was being highlighted by so many for so long - ICMR finally wakes up.
https://www.hindustantimes.com/india-news/icmr-gives-nod-for-rapid-antibody-test-to-detect-covid-19-in-hotspot-areas/story-yW35kCeXHJk4PSiESHygCK.html

The">https://www.hindustantimes.com/india-new... other key benefit, if they see this through, would be identifying potential plasma donors from those who recover. Good move.

ICMR gives nod for rapid antibody test to detect Covid-19 in hotspot areas - india news - Hindustan...

The Indian Council of Medical Research has framed a newer strategy for areas reporting in clusters (containment zone), in large migration gatherings and evacuee’s centres, where large number of...

https://www.hindustantimes.com/india-news/icmr-gives-nod-for-rapid-antibody-test-to-detect-covid-19-in-hotspot-areas/story-yW35kCeXHJk4PSiESHygCK.html

Yessssss!

There is a paper on this somewhere in this thread too.

Gilead switching to “expanded access” from a “compassionate use” program for Remdesivir. More than 1,700 patients have been treated through these programs. https://www.bloomberg.com/news/articles/2020-04-04/gilead-to-donate-experimental-coronavirus-drug-for-140-000-cases?cmpid=socialflow-twitter-business&utm_campaign=socialflow-organic&utm_medium=social&utm_source=twitter&utm_content=business">https://www.bloomberg.com/news/arti...

Gilead to Donate Experimental Coronavirus Drug for 140,000 Cases

Gilead Sciences Inc. said it’s donating 1.5 million doses of its experimental anti-coronavirus drug remdesivir, which could treat 140,000 patients.

https://www.bloomberg.com/news/articles/2020-04-04/gilead-to-donate-experimental-coronavirus-drug-for-140-000-cases?cmpid=socialflow-twitter-business&utm_campaign=socialflow-organic&utm_medium=social&utm_source=twitter&utm_content=business

While India will indulge in some hollow symbolism egged on by a clueless government, the cavalry of science is well and truly on the move elsewhere.

Kudos to the science, research and medical community for their hunt for a solution while god sleeps. https://www.sciencedirect.com/science/article/pii/S0166354220302011">https://www.sciencedirect.com/science/a...

The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited…

https://www.sciencedirect.com/science/article/pii/S0166354220302011

Atom-by-atom simulation of the coronavirus spike protein. The virus uses the stray grey ribbon at the top of the spike protein to attach to and invade healthy human cells.
Video: Lorenzo Casalino, Zied Gaieb, Rommie Amaro /UC SAN DIEGO
https://cutt.ly/8tKbpWl ">https://cutt.ly/8tKbpWl&q...

The best article i have read on the #COVID19 . Factors in almost all aspects arnd the mechanism,biochemical processes,genetic transfer,the proteins,cytokine & immune system & the routes being taken by the cavalry of science for possible treatment measures https://twitter.com/sarahzhang/status/1248251196558753794?s=20">https://twitter.com/sarahzhan...

https://twitter.com/sarahzhang/status/1248251196558753794?s=20

And @sarahzhang ,the links provided within your piece, all taken together - terrific job.Writing on the science of this stuff is not easy - but i think you have managed to convert the knowledge into very easily comprehensible bits. Easy to take in and make sense of the whole.

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