SARS-CoV-2: A Storm is Raging: Our Preview/Perspective for Chen on JCI: by day 8 after infection, it& #39;s cytokine storm and CD4/CD8 decrease that causes respiratory failure, not viral load. Agree w/ Stanley Perlman & @VirusesImmunity
http://shorturl.at/frwxZ ">https://shorturl.at/frwxZ&quo... http://shorturl.at/dJMN5 ">https://shorturl.at/dJMN5&quo...

This is the first peer-reviewed study characterizing cytokine profiles, CD4 count and T cell function in SARS-CoV-2-infected individuals. Cytokine storm correlates with disease severity.

Thanks to @jclinicalinvest @soupvector for this opportunity to contribute our thoughts, put together by our oustanding premed Savannah Pedersen.

@FilippoVeglia81 @VirusesImmunity We don& #39;t know about how asymptomatic patients respond to SARS-CoV-2 yet. Immunologic study on immunologic responses of asymptomatic patients responded is urgently needed to direct human response to protective immunity.

Here is the full link in case the above doesn& #39;t work:
Preview: https://www.jci.org/articles/view/137647
Original">https://www.jci.org/articles/... article: https://www.jci.org/articles/view/137244
Also">https://www.jci.org/articles/... check the mechanisms of cytokine storms by Stanley Perlman for the old SARS-CoV: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(16)30006-3">https://www.cell.com/cell-host...

Check out these papers, in which single-cell profiling of immune cells and cytokine storm has been done:
https://www.medrxiv.org/content/10.1101/2020.02.18.20024364v1">https://www.medrxiv.org/content/1... https://www.medrxiv.org/content/10.1101/2020.02.23.20026690v1">https://www.medrxiv.org/content/1...