The causes Shawn Mendes has supported (thread):

In 2014, Shawn teamed up with http://DoSomething.org  to launch his campaign #NotesFromShawn, the aim of which was to help those struggling with depression and self-harm. https://twitter.com/ShawnMendes/status/504669270836785152
In 2015, Shawn relaunched the campaign and partnered up with BlendApp with the aim of raising $25k for http://DoSomething.org . $1 was raised for every signup and positive message shared on the application. https://twitter.com/ShawnMendes/status/628670300947787776
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