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[THREAD]
Is HydroxyChloroquine an effective treatment for COVID-19?
* Used as treatment and in clinical studies: China, South Korea, Singapore, Spain, Belgium, Sweden, France, Brazil, UK, Canada, and US.
* Zinc + Zinc Ionophore (Quercetin)
* Media Attacks Chloroquine
![[THREAD]Is HydroxyChloroquine an effective treatment for COVID-19?* Used as treatment and in clinical studies: China, South Korea, Singapore, Spain, Belgium, Sweden, France, Brazil, UK, Canada, and US.* Zinc + Zinc Ionophore (Quercetin)* Media Attacks Chloroquine](https://pbs.twimg.com/media/ET3DyJJUEAUs6oX.jpg "[THREAD]Is HydroxyChloroquine an effective treatment for COVID-19?* Used as treatment and in clinical studies: China, South Korea, Singapore, Spain, Belgium, Sweden, France, Brazil, UK, Canada, and US.* Zinc + Zinc Ionophore (Quercetin)* Media Attacks Chloroquine")
Is HydroxyChloroquine an effective treatment for COVID-19?
* Used as treatment and in clinical studies: China, South Korea, Singapore, Spain, Belgium, Sweden, France, Brazil, UK, Canada, and US.
* Zinc + Zinc Ionophore (Quercetin)
* Media Attacks Chloroquine
2/ Hydroxychloroquine and Chloroquine have gained a lot of attention over the last week as Elon Musk and President Trump have expressed their optimism in the antiviral medications. https://twitter.com/elonmusk/status/1239650597906898947
3/ Elon Musk shares this popular youtube video from "MedCram" on the effectiveness of Zinc and Hydroxychloroquine.
4/ The best summary can be found here:
https://twitter.com/valkenburgh/status/1238654358465757184
"Zinc is doing the work but needs hydroxychloroquine, a zinc ionophore, to cross cellular membranes. Quercetin is a zinc ionophore which is an existing plant-based supplement available over the counter."
https://twitter.com/valkenburgh/status/1238654358465757184
"Zinc is doing the work but needs hydroxychloroquine, a zinc ionophore, to cross cellular membranes. Quercetin is a zinc ionophore which is an existing plant-based supplement available over the counter."
5/ Elon Musk shares some additional research.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998
https://www.elsevier.com/__data/assets/pdf_file/0007/988648/COVID-19-Drug-Therapy_Mar-2020.pdf
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998
https://www.elsevier.com/__data/assets/pdf_file/0007/988648/COVID-19-Drug-Therapy_Mar-2020.pdf
6/ There already seems to be a significant amount of research on the effectiveness of Zinc and Zinc-Ionophores against a variety of RNA viruses, including SARS-coronavirus. This was published November of 2010.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
7/ This research on concludes that chloroquine is effective in preventing the spread of SARS CoV in cell cultures. It was published in August of 2005.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/
8/ Here are two doctors from Montreal who are proposing the use of Quercetin which some research suggest can protect against the Ebola and Zika viruses, may be able to treat the coronavirus.
https://www.mcgilltribune.com/sci-tech/montreal-researchers-propose-a-treatment-for-covid-19-170320/
https://www.mcgilltribune.com/sci-tech/montreal-researchers-propose-a-treatment-for-covid-19-170320/
9/ Here is the French study that concluded, despite a small sample size, hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19.
https://www.sciencedirect.com/science/article/pii/S0924857920300996
https://www.sciencedirect.com/science/article/pii/S0924857920300996
10/ One of the best resources for me has been this Medium article from @adrianbye.
"Does Italy Have More COVID19 Deaths Than South Korea Because They’re Not Prescribing Chloroquine?" https://medium.com/@adrianbye/is-the-high-coronavirus-death-rate-caused-by-wrong-official-treatment-guidelines-f4ef0a2903f3
"Does Italy Have More COVID19 Deaths Than South Korea Because They’re Not Prescribing Chloroquine?" https://medium.com/@adrianbye/is-the-high-coronavirus-death-rate-caused-by-wrong-official-treatment-guidelines-f4ef0a2903f3
11/ This article made it much more apparent that China and South Korea have been using Chloroquine and Hydroxychloroquine as a treatment for COVID-19.
12/ Here is an article from February 17th in the Chinese Press saying that Chloroquine has been confirmed effective on COVID-19.
http://www.xinhuanet.com/english/2020-02/17/c_138792545.htm
http://www.xinhuanet.com/english/2020-02/17/c_138792545.htm
13/ Here is research published on March 9th with the conclusion that Hydroxychloroquine was found to be more potent than chloroquine to inhibit SARS-CoV-2 in vitro.
https://www.ncbi.nlm.nih.gov/pubmed/32150618
https://www.ncbi.nlm.nih.gov/pubmed/32150618
14/ Here is research from March 16th showing an apparent efficacy and acceptable safety of chloroquine phosphate as a treatment of COVID-19.
https://pubmed.ncbi.nlm.nih.gov/32074550/
https://pubmed.ncbi.nlm.nih.gov/32074550/
15/ The medium article also shared that Hydroxychloroquine is now being used in Spain, Belgium, Sweden, France, Brazil, USA, and UK.
16/ Here it is in Belgium:
https://www.levif.be/actualite/sante/coronavirus-une-molecule-vient-au-secours-des-patients-hospitalises/article-news-1265287.html?cookie_check=1584576524
https://www.levif.be/actualite/sante/coronavirus-une-molecule-vient-au-secours-des-patients-hospitalises/article-news-1265287.html?cookie_check=1584576524
17/ Here it is in Sweden:
https://www.svt.se/nyheter/inrikes/malarialakemedel-satts-in-hos-coronapatienter
https://www.svt.se/nyheter/inrikes/malarialakemedel-satts-in-hos-coronapatienter
18/ Here it is in France (previously mentioned study in Science Direct):
https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
19/ Here it is in Brazil:
https://www.focus.jor.br/hospital-albert-einstein-vai-testar-a-hidroxicloroquina-contra-o-covid-19/
https://www.focus.jor.br/hospital-albert-einstein-vai-testar-a-hidroxicloroquina-contra-o-covid-19/
20/ Here it is in Canada:
https://thepostmillennial.com/canada-is-already-using-chloroquine-on-coronavirus-patients
https://thepostmillennial.com/canada-is-already-using-chloroquine-on-coronavirus-patients
21/ Here it is in Spain:
Attached image come from a set of guidelines published by a Spanish healthcare association. https://twitter.com/smfarmhosp_smfh/
A medical researcher translated it into english. https://twitter.com/PiotrOkupski/
Attached image come from a set of guidelines published by a Spanish healthcare association. https://twitter.com/smfarmhosp_smfh/
A medical researcher translated it into english. https://twitter.com/PiotrOkupski/
22/ New York is going to begin drug trial test for chloroquine and hydroxychloroquine on Tuesday. https://www.forbes.com/sites/lisettevoytko/2020/03/22/new-york-to-begin-clinical-trials-for-coronavirus-treatment-tuesday-cuomo-says/#1b6426024203
23/ How has the Mainstream Media covered Hydroxychloroquine since mentioned by the President?
No coverage about it being used & researched in 10+ countries or the science behind zinc and zinc ionophores.
Instead a couple overdosed on fish tank cleaner and 2 grams can kill you.
No coverage about it being used & researched in 10+ countries or the science behind zinc and zinc ionophores.
Instead a couple overdosed on fish tank cleaner and 2 grams can kill you.
24/ This is after Korean physicians shared hydroxycholoroquine in official treatment guidelines on March 13th. While there still needs to be clinical studies with larger sample sizes, I am cautiously optimistic on the potential treatment.
http://www.koreabiomed.com/news/articleView.html?idxno=7428
http://www.koreabiomed.com/news/articleView.html?idxno=7428
25/ The National Task Force for COVID-19 in India has recommended hydroxychloroquine against COVID-19.
https://www.mohfw.gov.in/pdf/AdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection.pdf
Credit to @JamesTodaroMD
https://www.mohfw.gov.in/pdf/AdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection.pdf
Credit to @JamesTodaroMD
26/ I'm now realizing that Korea posted their treatment guidelines utilizing hydroxychloroquine as a treatment for COVID-19 on Feb 13th.
China's Head of Biotech said that chloroquine was selected out of tens of thousands of drugs as the most effective treatment on Feb 17th.
China's Head of Biotech said that chloroquine was selected out of tens of thousands of drugs as the most effective treatment on Feb 17th.
27/ Why did it take so long for the CDC and FDA to begin clinical trials in the US?
Why did the WHO only launch their "Solidarity Trial" of clinical studies on chloroquine on March 18th?
Why did all of this only happen after @elonmusk tweet went viral on March 16th?
Why did the WHO only launch their "Solidarity Trial" of clinical studies on chloroquine on March 18th?
Why did all of this only happen after @elonmusk tweet went viral on March 16th?
28/ "A physician in New York state claims he has used the anti-malaria drug hydroxychloroquine and zinc to treat 350 patients for COVID-19 with 100 percent success." https://forward.com/news/national/442285/coronavirus-hydroxychloroquine-trump-doctor/
29/ Breaking: Bahrain says drug touted by Trump as possible treatment for coronavirus is working effectively on its patients. https://justthenews.com/politics-policy/coronavirus/bahrain-hydroxychloroquine-success-response-covid-19
30/ India has banned the export of hydroxychloroquine. https://twitter.com/ReutersIndia/status/1242645765119528962
31/ Bloomberg article from February 4th, 2020.
"Chinese scientists have found... chloroquine, “highly effective” in laboratory studies at thwarting the coronavirus, they said Tuesday in a paper in the journal Cell Research."
https://www.bloomberg.com/news/articles/2020-02-05/china-is-trying-to-patent-gilead-s-experimental-coronavirus-drug
"Chinese scientists have found... chloroquine, “highly effective” in laboratory studies at thwarting the coronavirus, they said Tuesday in a paper in the journal Cell Research."
https://www.bloomberg.com/news/articles/2020-02-05/china-is-trying-to-patent-gilead-s-experimental-coronavirus-drug
32/ Chinese health officials announce on CCTV on February 17th, that after testing tens of thousands of medications, they've found Chloroquine to be the most effective against COVID-19 in clinical trials.
33/ The United States FDA has issued an emergency use authorization of anti-malaria drug Hydroxychloroquine to be prescribed to COVID-19 patients.
https://www.politico.com/amp/news/2020/03/29/fda-emergency-authorization-anti-malaria-drug-155095
https://www.politico.com/amp/news/2020/03/29/fda-emergency-authorization-anti-malaria-drug-155095
