Older people tend to have more of a matured immune response & are dying because their systems react more powerfully to #covid19.

This elevated immune reaction is the main cause of death for the elderly.

#Chloroquine can act as an immune suppressant - We need to use this now

My initial tweet is an attempt, in a general way, to explain one of the ways that #Hydroxychloroquine can be beneficial to #covid19 patients. I'm not a healthcare professional or a medical expert but I do know research & here's a great writeup from Indgon explaining further...

What Is #Hydroxychloroquine? Approved in 1955 originally and gained popularity for soldiers returning to the US from areas prone to malaria.

Hydroxychloroquine (HCQ) sulfate, a derivative of CQ, was first synthesized in 1946 in Germany by introducing a hydroxyl group into CQ...

It's on the WHO's list of safest and most effective medications needed in a health system.

These days, hydroxychloroquine has two different uses:

1. Anti-malarial agent
2. Autoimmune medication (like for rheumatoid arthritis or Lupus, etc)...

The two aforementioned uses or pathways are as follows:

1. Hydroxychloroquine raises the PH (acid/base) level in the specific parts of the cell that govern genetic replication

2.Hydroxychloroquine calms the IMMUNE RESPONSE (specifically TLR4 which responds to bacteria)...

How does #Hydroxychloroquine work for #coronavirus?

First, why the coronavirus so different.

Coronaviruses are a common class of virus that we come into contact each year.

The average person has 3-4 diff infections w coronaviruses each year ie. a common cold w mild symptoms...

Why is Covid19 so difficult?

There appears to be a diff in its "spike", or hooks that project fr the center circle making it very eff. at accessing our ACE2 receptors.

Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus (CoV) designated SARS-CoV...

This is important as the primary cause of death is acute pneumonia or the lungs being overwhelmed by both virus and, our IMMUNE RESPONSE.

ACE2 rec. are primarily in our cardiovascular system within the epithelial layer (the "skin" of our plumbing system)- primarily our lungs...

Bottom line, Covid19 has an improved ability to access our cells via this ACE2 receptor.

This is very odd for coronaviruses as its usually found in other very dangerous viruses such as HIV, influenza, dengue fever, SARS-CoV 2[13] etc...

CV mode of operation:

Once it gains access to our cell (via the spike mentioned above), it takes control of our cellular machinery making more of it.

CV primarily carry out this work in endosomes within cells.

The output from the endosome then goes out to the lysosome...

Hydroxychloroquine's effect is this:

The sp trigger depends on the virus' very & involve the exposure to the low pH of the late endosome.

A primary effect of hydroxychloroquine is to raise the PH levels in the endosome as both CQ/HCQ are weak bases known to elevate the pH...

With HCQ they're finding that Covid is not making it th the PH gauntlet along the endosome assembly line (fr EE early endo to EL late endo). Or, CV goes in but does not come out. A 10 fold reduction: (29% fr - 2% on the bk)

HCQ kills Covid's ability to replicate w/ PH!...

There's a secondary effect of hydroxychloroquine on the spike of the coronavirus.

In addition, CQ could inhibit SARS-CoV entry through changing the glycosylation of ACE2 receptor & spike protein.

Chloroquine (& by default, hydroxychloroquine) can reset the code so to speak...

Finally, if I've left anything out or I'm wrong in anyway feel free to contribute to the conversation with valid info or data.

I thought it was important to clarify my first tweet with what I believe to be, relevant data confirming my statement.