CRS management algorithm (adults) via @MDAndersonNews. This may be applicable to COVID19. https://www.mdanderson.org/documents/for-physicians/algorithms/clinical-management/clin-management-cytokine-release-web-algorithm.pdf">https://www.mdanderson.org/documents...
CRS management algorithm (adults) via @MDAndersonNews. This may be applicable to COVID19. https://www.mdanderson.org/documents...
CRS management algorithm (adults) via @MDAndersonNews. This may be applicable to COVID19. https://www.mdanderson.org/documents...
Pediatric version. https://www.mdanderson.org/documents/for-physicians/algorithms/clinical-management/clin-management-cytokine-release-pedi-web-algorithm.pdf">https://www.mdanderson.org/documents...
Interim Recommendations for the use of Tocilizumab in the Management of Patients who have Severe
COVID-19 with Suspected Hyperinflammation: https://www.hse.ie/eng/about/who/acute-hospitals-division/drugs-management-programme/interim-recommendations-for-the-use-of-tocilizumab-in-the-management-of-patients-with-severe-covid-19.pdf">https://www.hse.ie/eng/about... #toci #COVID19 #CRS #sCRS
Via @YaleIMed
Via @YaleIMed
Via @YaleIMed
Via @YaleIMed
https://twitter.com/romeerizwan/status/1243648232443580417?s=20">https://twitter.com/romeerizw...
https://twitter.com/RuthClifford5/status/1240046945206501377?s=20">https://twitter.com/RuthCliff...
https://twitter.com/sesiegler/status/1224697637464616960?s=20">https://twitter.com/sesiegler...
https://twitter.com/kaufm020/status/1243930359290458117?s=21">https://twitter.com/kaufm020/... https://twitter.com/kaufm020/status/1243930359290458117">https://twitter.com/kaufm020/...
From when the #toci label was expanded to include post CAR T cell CRS/sCRS: https://twitter.com/sesiegler/status/903042308446314496?s=21">https://twitter.com/sesiegler... https://twitter.com/sesiegler/status/903042308446314496">https://twitter.com/sesiegler...
https://twitter.com/sesiegler/status/1242467643530993664?s=21">https://twitter.com/sesiegler... https://twitter.com/sesiegler/status/1242467643530993664">https://twitter.com/sesiegler...
https://twitter.com/3dimmune/status/1245083662644887552?s=21">https://twitter.com/3dimmune/... https://twitter.com/3DiMMUNE/status/1245083662644887552">https://twitter.com/3DiMMUNE/...
https://twitter.com/yaleimed/status/1245353636617732099?s=21">https://twitter.com/yaleimed/... https://twitter.com/yaleimed/status/1245353636617732099">https://twitter.com/yaleimed/...
https://twitter.com/sesiegler/status/1098698756059475968?s=21">https://twitter.com/sesiegler... https://twitter.com/sesiegler/status/1098698756059475968">https://twitter.com/sesiegler...
https://www.bioworld.com/articles/433890-humanigen-preps-lenzilumab-for-potential-battle-with-deadly-covid-19-symptom">https://www.bioworld.com/articles/...
Humanigen preps lenzilumab for potential battle with deadly COVID-19 symptom

Humanigen Inc., the Burlingame, Calif.-based developer of an anti-human-GM-CSF monoclonal antibody for preventing and treating cytokine storms, is urgently working to spin up a phase III trial of the...

https://www.bioworld.com/articles/433890-humanigen-preps-lenzilumab-for-potential-battle-with-deadly-covid-19-symptom
https://www.bignewsnetwork.com/news/264481238/humanigen-partners-with-cti-a-leading-contract-research-organization-for-planned-phase-iii-study-for-lenzilumab-for-coronavirus-treatment">https://www.bignewsnetwork.com/news/2644...
Humanigen Partners With CTI, A Leading Contract Research Organization, For Planned Phase III Study...

Study to Tackle Leading Cause of Death in COVID-19 PatientsLenzilumab a monoclonal antibody that neutralizes granulocyte macrophage colony stimulating factor

https://www.bignewsnetwork.com/news/264481238/humanigen-partners-with-cti-a-leading-contract-research-organization-for-planned-phase-iii-study-for-lenzilumab-for-coronavirus-treatment
https://twitter.com/drug_smolecules/status/1246157112981553157?s=21">https://twitter.com/drug_smol... https://twitter.com/drug_smolecules/status/1246157112981553157">https://twitter.com/drug_smol...
Anakinra! https://www.trialsitenews.com/sobis-anakinra-emapalumab-requested-for-use-in-targeted-clinical-study-in-italy-to-address-severe-covid-19-cases/">https://www.trialsitenews.com/sobis-ana...
Sobi’s Anakinra & Emapalumab Requested for Use in Targeted Clinical Study in Italy to Address...

A publicly traded Swedish biotech will soon launch a short-term clinical trial evaluating the efficacy and safety of anakinra and emapalumab to treat

https://www.trialsitenews.com/sobis-anakinra-emapalumab-requested-for-use-in-targeted-clinical-study-in-italy-to-address-severe-covid-19-cases/
https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%2820%2930628-0%2Ffulltext&rc=0">https://secure.jbs.elsevierhealth.com/action/ge...
Has anyone tried hemofiltration for COVID19 induced CRS? https://pubmed.ncbi.nlm.nih.gov/30198955/ ">https://pubmed.ncbi.nlm.nih.gov/30198955/...
Hemofiltration Successfully Eliminates Severe Cytokine Release Syndrome Following CD19 CAR-T-Cell...

Cytokine release syndrome (CRS) remains to be a major adverse effect of chimeric antigen receptor T (CAR-T) cell therapy in B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. It was urgent to...

https://pubmed.ncbi.nlm.nih.gov/30198955/
How about plasma exchange? https://twitter.com/sesiegler/status/1052296353550950400?s=21">https://twitter.com/sesiegler... https://twitter.com/sesiegler/status/1052296353550950400">https://twitter.com/sesiegler...
https://www.karger.com/Article/Fulltext/492379">https://www.karger.com/Article/F...
Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory...

https://www.karger.com/Article/Fulltext/492379
Another idea: Itacitinib (ITA) https://www.sciencedirect.com/science/article/pii/S1083879119313655">https://www.sciencedirect.com/science/a...
Trial in Progress: A Phase 2, Single-Arm, Open-Label Study of Itacitinib (ITA) for the Prevention...

Anti-CD19 CAR T cells have emerged as a powerful immunotherapeutic tool for treating B-cell malignancies. Tisagenlecleucel (tisa-cel) and axicabtagene…

https://www.sciencedirect.com/science/article/pii/S1083879119313655
I started tweeting about #toci as a potential tx for COVID19 on Feb 4. @sitcancer put out this editorial on March 24. https://www.sitcancer.org/research/covid-19-resources/il-6-editorial">https://www.sitcancer.org/research/...
Jakafi is going to be tested. https://medcitynews.com/2020/04/incyte-plans-phase-iii-trial-of-blood-cancer-drug-as-potential-covid-19-cytokine-storm-therapy/">https://medcitynews.com/2020/04/i...
Incyte plans Phase III trial of blood cancer drug as potential Covid-19 cytokine storm therapy -...

The company said it is working with the FDA to start a Phase III study of Jakafi in Covid-19-associated cytokine storm, which may be behind severe disease in some patients and for which JAK inhibit...

https://medcitynews.com/2020/04/incyte-plans-phase-iii-trial-of-blood-cancer-drug-as-potential-covid-19-cytokine-storm-therapy/
Another interesting trial (China): https://clinicaltrials.gov/ct2/show/NCT04306705">https://clinicaltrials.gov/ct2/show/...
Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19 - Full Text View -...

Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19 - Full Text View.

https://clinicaltrials.gov/ct2/show/NCT04306705
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