Read on Twitter
CRS management algorithm (adults) via @MDAndersonNews. This may be applicable to COVID19. https://www.mdanderson.org/documents/for-physicians/algorithms/clinical-management/clin-management-cytokine-release-web-algorithm.pdf
Pediatric version. https://www.mdanderson.org/documents/for-physicians/algorithms/clinical-management/clin-management-cytokine-release-pedi-web-algorithm.pdf
Interim Recommendations for the use of Tocilizumab in the Management of Patients who have Severe
COVID-19 with Suspected Hyperinflammation: https://www.hse.ie/eng/about/who/acute-hospitals-division/drugs-management-programme/interim-recommendations-for-the-use-of-tocilizumab-in-the-management-of-patients-with-severe-covid-19.pdf #toci #COVID19 #CRS #sCRS
COVID-19 with Suspected Hyperinflammation: https://www.hse.ie/eng/about/who/acute-hospitals-division/drugs-management-programme/interim-recommendations-for-the-use-of-tocilizumab-in-the-management-of-patients-with-severe-covid-19.pdf #toci #COVID19 #CRS #sCRS
Via @YaleIMed
https://twitter.com/kaufm020/status/1243930359290458117?s=21 https://twitter.com/kaufm020/status/1243930359290458117
From when the #toci label was expanded to include post CAR T cell CRS/sCRS: https://twitter.com/sesiegler/status/903042308446314496?s=21 https://twitter.com/sesiegler/status/903042308446314496
https://twitter.com/sesiegler/status/1242467643530993664?s=21 https://twitter.com/sesiegler/status/1242467643530993664
https://twitter.com/3dimmune/status/1245083662644887552?s=21 https://twitter.com/3DiMMUNE/status/1245083662644887552
https://twitter.com/yaleimed/status/1245353636617732099?s=21 https://twitter.com/yaleimed/status/1245353636617732099
https://twitter.com/sesiegler/status/1098698756059475968?s=21 https://twitter.com/sesiegler/status/1098698756059475968
https://twitter.com/drug_smolecules/status/1246157112981553157?s=21 https://twitter.com/drug_smolecules/status/1246157112981553157
Has anyone tried hemofiltration for COVID19 induced CRS? https://pubmed.ncbi.nlm.nih.gov/30198955/
How about plasma exchange? https://twitter.com/sesiegler/status/1052296353550950400?s=21 https://twitter.com/sesiegler/status/1052296353550950400
Another idea: Itacitinib (ITA) https://www.sciencedirect.com/science/article/pii/S1083879119313655
I started tweeting about #toci as a potential tx for COVID19 on Feb 4. @sitcancer put out this editorial on March 24. https://www.sitcancer.org/research/covid-19-resources/il-6-editorial
Jakafi is going to be tested. https://medcitynews.com/2020/04/incyte-plans-phase-iii-trial-of-blood-cancer-drug-as-potential-covid-19-cytokine-storm-therapy/
Another interesting trial (China): https://clinicaltrials.gov/ct2/show/NCT04306705
