Chronic social isolation causes upregulation of Kappa opioid receptors, which in turn causes the inhibition of both GABA AND dopamine, the two most vital neurotransmitters in mental/emotional health.

Individuals with C/PTSD, depression of all types, anxiety of all types, OCD, bipolar, schizophrenia, and ESPECIALLY addiction are most prone to suffering the worst in the situation at hand. If you have any friends or family with these conditions, PLEASE reach out to them.

High dynorphin expression is one of the most depressed and fearful/anxious, even painful, states one can experience.

Now, there is hope here. You MUST focus on socialization, even on social media. Give anyone a call or text. Mute keywords and take breaks if necessary.

Stress of all kinds impacts KOPr.

Exercise is going to be your best friend here. Bodyweight is going to be most optimal in most peoples' situations right now, but if possible, order a set of dumbbells or a barbell.

Exercise, especially chronically, downregulates KOPr and upregulates Mu opioid receptors, or the feel good endorphin expression. Exercise MATTERS. It may be painful at first, but remember you gotta use energy to have energy. Stick it out and it WILL help.

Wim Hof is a breathing method that increases hedonic tone (MOPr > KOPr), as well as being highly anti-inflammatory.

Start with one breath cycle 1-2 times a day and work your way up.

Raw cacao and thymoquinone in black seed oil are both TLR4 antagonists, which causes upregulation of endorphins and enkephalins, when consumed chronically, as well as providing a mood lift and pain relief.

(Ultra) Low Dose Naltrexone can be used for the same purpose if one can acquire it with minimal to no side effects.

Magnesium is also going to be vital. Magnesium glycinate and L-theanine make for an excellent GABAergic, neurotrophic combination that also possesses anti-inflammatory properties, especially for the brain and nervous system.

Daily direct sunlight exposure is VITAL to beta-endorphin production. Early morning on the eyes, face, and back of neck is best, but noon and sunset are excellent times as well. Really, any sun is better than none!

Honorable mentions: hesperidin in citrus peels (eat the pith too) and menthol also act as Kappa opioid receptor agonists and can be consumed chronically to downregulate dynorphin expression.

DLPA and Agmatine are also two supplements that help with beta-endorphin production.

Remember, you're never alone. I love you and there are other people that love and care for you too. Now get off your ass and get serious about your health.