In celebration of the #ISN60years, the ISN Research Working Group will publish a monthly series, “Breakthrough Discoveries”. This series will highlight 60 + 1 historical discoveries of significant impact to the nephrology community.

Read more: https://www.theisn.org/60th-anniversary/breakthrough-discoveries
1⃣ First microscopic description of the "glomeruli"
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-january/first-microscopical-description-of-the-glomeruli #ISN60years
2⃣ Identification of kidney disease
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-january/identification-of-kidney-disease #ISN60years
3⃣ Description of the nephron
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-january/description-of-the-nephron #ISN60years
4⃣ Description of the urinary sediment as a tool for the diagnosis of nephropathies
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-january/description-of-the-urinary-sediment-as-a-tool-for-the-diagnosis-of-nephropathies #ISN60years
5⃣ Routine measurement of urea and creatinine in clinical practice
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-january/routine-measurement-of-bun-and-creatinine-in-clinical-practice #ISN60years
6⃣ Discovery of the Nephron Loop
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-february/discovery-of-the-nephron-loop #ISN60years
7⃣ Micropuncture Technique
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-february/micropuncture-technique #ISN60years
8⃣ Demonstration of Renal Physiology
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-february/demonstration-of-renal-physiology #ISN60years
9⃣ Description of Acute Renal Failure with Crush Syndrom
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-february/description-of-acute-renal-failure-with-crush-syndrome #ISN60years
🔟 Laboratory Methods for Clinical Application to treat Kidney Disease
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-february/laboratory-methods-for-clinical-application-to-treat-kidney-disease #ISN60years
1⃣1⃣ Volhard & Fahr’s book
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-march/volhard-fahr-s-book #ISN60years
1⃣2⃣ Percutaenous kidney biopsy
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-march/percutaenous-kidney-biopsy #ISN60years
1⃣3⃣ Application of immune fluorescence technique to kidney biopsy – Mellors 1950s
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-march/application-of-immune-fluorescence-technique-menu #ISN60years
1⃣4⃣ Application of electron microscopy to analyze ultrastructural changes of the kidney
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-march/application-of-electron-microscopy-menu #ISN60years
1⃣5⃣ Structure-function correlation in the glomerulus
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-march/structure-function-correlation-glomerulus-menu #ISN60years
1⃣6⃣ Understanding of acid excretion in kidney disease
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-april/understanding-of-acid-excretion-in-kidney-disease #ISN60years
1⃣7⃣ Perfusion of isolated tubules
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-april/perfusion-of-isolated-tubules #ISN60years
1⃣8⃣ Understanding of nephron membrane transport systems by means of isolated membranes and cells
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-april/understanding-of-nephron-membrane-transport-systems-by-means-of-isolated-membranes-and-cells #ISN60years
1⃣9⃣ Countercurrent multiplication system without active transport
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-april/countercurrent-multiplication-system-without-active-transport #ISN60years
2⃣0⃣ Identification of molecules
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-april/identification-of-molecules #ISN60years
2⃣1⃣ Description of Minimal Change Nephrotic Syndrome, “Lipoid Nephrosis”
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-may/description-of-minimal-change-nephrotic-syndrome-lipoid-nephrosis #ISN60years
2⃣2⃣ Culture of Glomerular Cells
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-may/culture-of-glomerular-cells #ISN60years
2⃣3⃣ Identification of Antigen of Membranous Nephropathy
https://www.theisn.org/60th-anniversary/breakthrough-discoveries/breakthroughs-in-may/identification-of-antigen-of-membranous-nephropathy #ISN60years
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