2019-nCoV
See previous WHO warning https://twitter.com/daniel_bilar/status/1151825818982715395
#ebola #sars

Pray especially for Hong Kong https://twitter.com/daniel_bilar/status/1155556585499967489 https://twitter.com/ewarner_12/status/1218251334102781955
https://www.bbc.com/news/health-51148303
New virus in China 'will have infected hundreds'

The virus emerged in December, two people have died and it has been detected in three countries.

https://www.bbc.com/news/health-51148303
Bat to Human jump #coronavirus https://www.ecohealthalliance.org/wp-content/uploads/2018/03/Virologica-Sinica-SARSr.pdf
@PeterDaszak "The other viruses w the nearest matching genetic sequences all originate in bats, likely incl SARS-CoV" #sars
Genome https://www.ncbi.nlm.nih.gov/nuccore/MN908947

Invisible to routine respiratory diagnostic http://virological.org/t/initial-assessment-of-the-ability-of-published-coronavirus-primers-sets-to-detect-the-wuhan-coronavirus/321
Bat to Human jump #coronavirus https://www.ecohealthalliance.org/wp-content/uploads/2018/03/Virologica-Sinica-SARSr.pdf @PeterDaszak "The other viruses w the nearest matching genetic sequences all originate in bats, likely incl SARS-CoV" #sars Genome https://www.ncbi.nlm.nih.gov/nuccore/MN908947Invisible to routine respiratory diagnostic http://virological.org/t/initial-assessment-of-the-ability-of-published-coronavirus-primers-sets-to-detect-the-wuhan-coronavirus/321
Bat to Human jump #coronavirus https://www.ecohealthalliance.org/wp-content/uploads/2018/03/Virologica-Sinica-SARSr.pdf @PeterDaszak "The other viruses w the nearest matching genetic sequences all originate in bats, likely incl SARS-CoV" #sars Genome https://www.ncbi.nlm.nih.gov/nuccore/MN908947Invisible to routine respiratory diagnostic http://virological.org/t/initial-assessment-of-the-ability-of-published-coronavirus-primers-sets-to-detect-the-wuhan-coronavirus/321
https://www.scmp.com/news/hong-kong/health-environment/article/3047022/wuhan-coronavirus-20-other-cities-china-affected
Wuhan virus a step closer to full-blown epidemic, expert warns

Hong Kong University’s Professor Yuen Kwok-yung, a top infectious diseases expert, says the transmission of the coronavirus has entered its ‘third wave’.

https://www.scmp.com/news/hong-kong/health-environment/article/3047022/wuhan-coronavirus-20-other-cities-china-affected
https://twitter.com/howroute/status/1219719424632152065
> Rail/air rravel to/from Wuhan restricted
> WHO delayed to Thursday decision on declaring a public health emergency
> "preliminary positive" virus reports Hong Kong
> potential vaccine could move into early-stage human testing in the next 3 months (same group as SARS / MERS)
China asks citizens to stop evading border checks for #nCoV2019 preventative screening

Wuhan woman w mild fever symptoms took meds to lower temp, flew to Paris, ate at (Michelin) rest. https://twitter.com/lauriechenwords/status/1220297571760914432

Global case map updated daily https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
Early basic reproduction R_0 estimates for #nCoV2019 range from 2.0 to 3.3 (WHO estimate R_0 = 1.4 to 2.5)

R_0 measure of transmissibility that aims to describe the average number of people a new case *in a fully susceptible population* could infect.

https://threadreaderapp.com/thread/1220501403057229824.html
Hong Kong declared a virus emergency, scrapped celebrations and restricted links to mainland China. https://twitter.com/AndrewSErickson/status/1221229715941470209
by @neil_ferguson R_0 = 2.6 [1.5-3.5]
"Control measures need to block well 60%+ of transmission to be effective in controlling the outbreak"
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/
1-2 weeks incubation, no symptoms (unlike SARS 2003)
IMHO v likely too late for quarantine https://twitter.com/daniel_bilar/status/1221247197565591555
by @neil_ferguson R_0 = 2.6 [1.5-3.5]"Control measures need to block well 60%+ of transmission to be effective in controlling the outbreak" https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/1-2 weeks incubation, no symptoms (unlike SARS 2003) IMHO v likely too late for quarantine https://twitter.com/daniel_bilar/status/1221247197565591555
by @neil_ferguson R_0 = 2.6 [1.5-3.5]"Control measures need to block well 60%+ of transmission to be effective in controlling the outbreak" https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/1-2 weeks incubation, no symptoms (unlike SARS 2003) IMHO v likely too late for quarantine https://twitter.com/daniel_bilar/status/1221247197565591555
by @neil_ferguson R_0 = 2.6 [1.5-3.5]"Control measures need to block well 60%+ of transmission to be effective in controlling the outbreak" https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/1-2 weeks incubation, no symptoms (unlike SARS 2003) IMHO v likely too late for quarantine https://twitter.com/daniel_bilar/status/1221247197565591555
Chartered flight repatriating ~240 Americans will refuel in Ak at ANC. North Terminal as a quarantine site for screening.

Zink: Americans will be screened before traveling out of China. If they show symptoms, they will not be allowed to board the flight.

https://twitter.com/M_curiosum/status/1221902693599457286
Australian researchers grow #ncov2019 culture for 1st time outside of China (took just 4 days bc the Aussies were prepared)
> develop antibody test
> retrospectively test suspected patients (mortality rates, update R_0 etc)
> effectiveness trial vaccines
https://twitter.com/coopesdetat/status/1222264840233705472
Chinese researchers: Remdesivir (GS-5734), Chloroquine (Sigma-C6628) & Ritonavir show fairly good inhibitory effects on #ncov2019 at cellular level https://twitter.com/CCTVAsiaPacific/status/1222704813764296704
US: “It will take three months to get it into the trial, three months to get safety, immunogenicity data.”
Chinese researchers: Remdesivir (GS-5734), Chloroquine (Sigma-C6628) & Ritonavir show fairly good inhibitory effects on #ncov2019 at cellular level https://twitter.com/CCTVAsiaPacific/status/1222704813764296704US: “It will take three months to get it into the trial, three months to get safety, immunogenicity data.”
Chinese researchers: Remdesivir (GS-5734), Chloroquine (Sigma-C6628) & Ritonavir show fairly good inhibitory effects on #ncov2019 at cellular level https://twitter.com/CCTVAsiaPacific/status/1222704813764296704US: “It will take three months to get it into the trial, three months to get safety, immunogenicity data.”
Chinese researchers: Remdesivir (GS-5734), Chloroquine (Sigma-C6628) & Ritonavir show fairly good inhibitory effects on #ncov2019 at cellular level https://twitter.com/CCTVAsiaPacific/status/1222704813764296704US: “It will take three months to get it into the trial, three months to get safety, immunogenicity data.”
Chinese researchers: Remdesivir (GS-5734), Chloroquine (Sigma-C6628) & Ritonavir show fairly good inhibitory effects on #ncov2019 at cellular level https://twitter.com/CCTVAsiaPacific/status/1222704813764296704US: “It will take three months to get it into the trial, three months to get safety, immunogenicity data.”
. @GileadSciences ships 500 doses of experimental #coronavirus drug Remdesivir (GS-5734) via @latlongpacific

> 10 infusions / day
> starts Feb 11 for 28 days
> R effective viz Ebola in the lab not in human trials
> earliest results in a couple months https://www.straitstimes.com/world/united-states/trials-of-gilead-coronavirus-drug-in-china-could-start-next-week?utm_term=Autofeed&utm_campaign=sttw&utm_medium=Social&utm_source=Twitter#Echobox=1580859333
Trials of Gilead coronavirus drug in China could start next week,

United States News -NEW YORK (BLOOMBERG) - Gilead Sciences Inc. is shipping enough doses of its experimental coronavirus drug to treat 500 patients in China and is ramping up supply in case clinical

https://www.straitstimes.com/world/united-states/trials-of-gilead-coronavirus-drug-in-china-could-start-next-week?utm_term=Autofeed&utm_campaign=sttw&utm_medium=Social&utm_source=Twitter#Echobox=1580859333
Unconfirmed claim #remdesivir drug price differential US retail price $0.02 USD vs China $35550￥
https://twitter.com/asdasd26700831/status/1224840084693798912

#coronavirus
US NIH: 1st clinical trial to test #Remdesivir GS-5734 @GileadSciences to treat #coronavirus [3 hospitalized patients @UNOmaha , NUC inhibitor, inhibits murine hepatitis & MERS; repurposes failed #ebola drug, previous https://twitter.com/daniel_bilar/status/1151825818982715395]
· https://www.jewishpress.com/news/us-news/first-clinical-trial-for-gilead-sciences-coronavirus-drug-begins/2020/02/26/ #ncov2019
US NIH: 1st clinical trial to test #Remdesivir GS-5734 @GileadSciences to treat #coronavirus [3 hospitalized patients @UNOmaha , NUC inhibitor, inhibits murine hepatitis & MERS; repurposes failed #ebola drug, previous https://twitter.com/daniel_bilar/status/1151825818982715395]· https://www.jewishpress.com/news/us-news/first-clinical-trial-for-gilead-sciences-coronavirus-drug-begins/2020/02/26/ #ncov2019
US NIH: 1st clinical trial to test #Remdesivir GS-5734 @GileadSciences to treat #coronavirus [3 hospitalized patients @UNOmaha , NUC inhibitor, inhibits murine hepatitis & MERS; repurposes failed #ebola drug, previous https://twitter.com/daniel_bilar/status/1151825818982715395]· https://www.jewishpress.com/news/us-news/first-clinical-trial-for-gilead-sciences-coronavirus-drug-begins/2020/02/26/ #ncov2019
US NIH: 1st clinical trial to test #Remdesivir GS-5734 @GileadSciences to treat #coronavirus [3 hospitalized patients @UNOmaha , NUC inhibitor, inhibits murine hepatitis & MERS; repurposes failed #ebola drug, previous https://twitter.com/daniel_bilar/status/1151825818982715395]· https://www.jewishpress.com/news/us-news/first-clinical-trial-for-gilead-sciences-coronavirus-drug-begins/2020/02/26/ #ncov2019
US NIH: 1st clinical trial to test #Remdesivir GS-5734 @GileadSciences to treat #coronavirus [3 hospitalized patients @UNOmaha , NUC inhibitor, inhibits murine hepatitis & MERS; repurposes failed #ebola drug, previous https://twitter.com/daniel_bilar/status/1151825818982715395]· https://www.jewishpress.com/news/us-news/first-clinical-trial-for-gilead-sciences-coronavirus-drug-begins/2020/02/26/ #ncov2019
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