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#funvaxfact placebo thread: I wanted to only focus on childhood vaccine trials with "inert"/saline placebos in kids since AVers love the "no true Scotsman" fallacy (h/t @handmadekathy). In the process, I found some great historical vaccine trials. Enjoy. #vaccinehistory
Disclaimer: saline is not the only choice of placebo & there are ethical considerations as to why placebos are not always used in vaccine trials but I wanted to show just how many saline studies there are. #VaccinesAreSafe
Thorough review of the topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157320/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Thorough review of the topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157320/">https://www.ncbi.nlm.nih.gov/pmc/artic...
First, there is the largest randomized placebo controlled trial ever conducted: the 1954 polio field trials. 1.8 million children were enrolled with 200,000 receiving saline placebo. The vaccine was an enormous success and now polio is on the brink of eradication #VaccinesWork
Measles - while some of the studies from the 1960s do not clearly describe the contents of the placebo, I found several double blind placebo controlled trials. Here are a few, including one that clearly describes saline placebo.
Mumps and Rubella? Also tested in a double blind saline placebo controlled study! Now you might say I& #39;m picking 50 year old studies bc there were more saline trials done back then. Unfortunately for antivaxxers, saline trials continue to happen today for new vaccines.
Hib & PCV were new vaccines in the & #39;90s. 1 Hib trial used sugar & 1 PCV trial used buffered saline (& a PCV trial from 2009 that also used saline). A different placebo Hib trial was so successful it was stopped early bc it was unethical to deny kids the vaccine #VaccinesSaveLives
What about the flu vaccine? There are many saline placebo studies for both intranasal live attenuated vaccine and inactivated injectable vaccine.
Here& #39;s one
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Here& #39;s one
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And">https://bit.ly/2XQ0nAI&q... another:
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And">https://bit.ly/2sdUy4i&q... another:
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And lastly, HPV. Many people claim that the HPV vaccine was not fairly assessed against saline placebo. This is hogwash. There are many saline studies. #EndHPVCancer
Here:
https://bit.ly/2OS4pEI
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https://bit.ly/35SDfod&q... href=" https://bit.ly/2q0jaNc ">https://bit.ly/2q0jaNc&q...
Here:
https://bit.ly/2OS4pEI
In conclusion, I do not think this thread will convince the diehard AVers. But I hope it can convince vaccine hesitant parents that the AV talking point about "no saline placebo studies" is completely & utterly false. This is dangerous misinformation promoted by RFK Jr & Bigtree.
Thanks to @crabb_vicki @AboutPediatrics @JHowardBrainMD @thereal_truther @Rosewind2007 @PedsID4Life for their contributions or inspiration in making this thread
