Ketogenic diet: 14 mechanisms of action #Keto

1. Lowers blood sugar & insulin levels

2. Decreases leptin

3. Produces ketone bodies, an alternate source of energy, instead of glucose

4. Changes neurotransmitters, GABA, glutamate, adenosine, as well as ion channel regulation
5. Increases mitochondrial function and production

6. Increases circulating PUFA’s – neuroprotective (PUFA’s are Polyunsaturated fatty acids that include Omega-3’s and Omega-6’s. )

7. Decreases inflammation

8. Up regulation of glutathione peroxidase (an antioxidant)
9. Lowers levels of IL-1β and inflammatory cytokines

10. Changes the gut microbiome

11. Changes DNA methylation and gene expression

12. Increases autophagy – removal of damaged cell parts

13. Increases nicotinamide adenine dinucleotide (NAD+)

14. Activates Sirtuin genes
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