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POTS is associated with orthostatic presyncope, postural tachycardia, palpitations, chest discomfort, dyspnea, and “brain fog”, but also chronic abdominal pain, migraine headache, chronic fatigue, hypermobility and musculoskeletal pain. https://www.autonomicneuroscience.com/article/S1566-0702(17)30338-7/fulltext
POTS is associated with orthostatic presyncope, postural tachycardia, palpitations, chest discomfort, dyspnea, and “brain fog”, but also chronic abdominal pain, migraine headache, chronic fatigue, hypermobility and musculoskeletal pain. https://www.autonomicneuroscience.com/article/S1566-0702(17)30338-7/fulltext
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POTS specialists note that antihistamines + other mast cell therapies help manage symptoms in some patients. Some patients describe allergic-like reactions to food, odors, medications, etc. POTS is considered secondary to a variety of mechanisms (BobS: like Ehlers Danlos).
POTS specialists note that antihistamines + other mast cell therapies help manage symptoms in some patients. Some patients describe allergic-like reactions to food, odors, medications, etc. POTS is considered secondary to a variety of mechanisms (BobS: like Ehlers Danlos).
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Li et al. who used double-labeled immunofluorescence to demonstrate co-localization of histamine and noradrenalin in sympathetic nerves suggesting that histamine might function as a neurotransmitter in modulation of sympathetic function
https://www.physiology.org/doi/full/10.1152/ajpheart.00939.2005
Li et al. who used double-labeled immunofluorescence to demonstrate co-localization of histamine and noradrenalin in sympathetic nerves suggesting that histamine might function as a neurotransmitter in modulation of sympathetic function
https://www.physiology.org/doi/full/10.1152/ajpheart.00939.2005
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Sensory nerves (implicated in small fiber neuropathy) can be activated by MC mediators and could convey effects throughout the body via neuronal transmission
Nerve excitability is affected by MC release. Trigeminal nerves are more reactive when leukotrienes are released
Sensory nerves (implicated in small fiber neuropathy) can be activated by MC mediators and could convey effects throughout the body via neuronal transmission
Nerve excitability is affected by MC release. Trigeminal nerves are more reactive when leukotrienes are released
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Tryptase activates neuronal receptors.
Other MC mediators lower the neuron's activation threshold (increase excitability)
This paper also references work demonstrating that the opposite is also true: mast cells have an enhanced susceptibility to nerve activation.
Tryptase activates neuronal receptors.
Other MC mediators lower the neuron's activation threshold (increase excitability)
This paper also references work demonstrating that the opposite is also true: mast cells have an enhanced susceptibility to nerve activation.
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Mast cells are found in high numbers in connective tissue (CT) and stretch alone causes mast cell degranulation. Persistent exaggerated stretch allowed by Ehlers Danlos, may cause mast cell degranulation.
Mast cells are found in high numbers in connective tissue (CT) and stretch alone causes mast cell degranulation. Persistent exaggerated stretch allowed by Ehlers Danlos, may cause mast cell degranulation.
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The paper concludes that
Stretch of the extracellular matrix permitted by Ehlers Danlos causes mast cell degranulation
Mast cells appear to be effectors of the autonomic system or may drive autonomic dysregulation
Mast cell activity may be increased by neuronal activity
The paper concludes that
Stretch of the extracellular matrix permitted by Ehlers Danlos causes mast cell degranulation
Mast cells appear to be effectors of the autonomic system or may drive autonomic dysregulation
Mast cell activity may be increased by neuronal activity
