#IFNs

Our latest study to understand the dynamic regulation of #interferon (#IFN) and #SARSCoV2 infection. summarizing what we found and what needs to be done to understand the dynamic interplay of
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Check out this very cool study from @casanova_lab hot off the press at @ScienceMagazine.It shows that very severe #COVID19 is associated with auto-antibodies against type I interferons.https://science.sciencemag.org/content/early/2020/09/23
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Survived another ASHG plenary talk :)In case you missed it, I presented results on behalf of @Regeneron from a trans-ancestry #COVID19 meta-analysis of common and rare variants + gene burden
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1/ Thread on the first 2 papers from the COVIDhge consortium (with my small contribution). The 2 studies show that genetic variants & auto-immunity to type 1 interferons explain 10-15%
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Another week and more data on the immune response to SARS-CoV2 and the disease it causes, COVID-19. This information is critical for therapeutic repurposing. A short thread on interferon and
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Very excited to share this work by the heroic team - @carolilucas Pat Wong @sneakyvirus @tiago21bio et al on “Longitudinal analyses reveal immunological misfiring in severe COVID-19”. A thread on
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Are you confused about the role of type I interferons (IFN) in #SARS_CoV_2 infection? Here is my speculation on what makes IFN-I helpful vs. harmful in #COVID19 patients - it
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Delighted to share our view on the use of #interferons #lambda #IFNL #TYPEIII #IFN as #therapeutics against #Covid_19 #SARSCoV2. This opinion comes form an amazing team effort. #openaccess 1/5 http://doi.org/10.1084/JEM.20200653
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Targeting inflammation to treat #ALS (#MND)! An exciting mechanistic insight by @AlanCHYu @WEHI_Research with @unimelb @TheFlorey @Hudson_Research. Our first foray into the neuro space! Read on for the scientific highlights
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Immunology is one of the hardest and most complicated processes to understand. 27 people have won Nobel Prizes for explaining parts of it. I'm going to hazard explaining how pandemic
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Really interesting (follows up on the case of two sets of brothers with severe COVID-19)https://www.sciencemag.org/news/2020/09/hidden-immune-weakness-found-14-gravely-ill-covid-19-patients We produce interferons in response to infections.
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/1 I received many questions from my most recent newsletter. I will do my best to answer them in this thread: Question from Lennart: Is it possible that statins would
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