Bruce Booth
LifeSciVC
As I understand it (h/t @ArtKrieg), HCQ/CQ block innate receptors like TLR7/8/9. Blocking these early during a SARS-CoV2 infection could exacerbate, not help in treating, COVID. Later in disease, during
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The innate immune system is key for fighting viral infections, but can go overboard with CRS during severe disease. But dampening it early in an infection is probably not smart.
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