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#TMPRSS2
Daniel Goldhill
influenzal
Very excited to share some of our lab’s work on SARS-CoV-2. This was a huge team effort – so many people in lab worked hard on this. This is still
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Adriaan
A_van_der_graaf
Today we're sharing an analysis of the genetics behind two important COVID-19 genes: ACE2 and TMPRSS2. A thread on what we have found 1/9https://www.medrxiv.org/content/10.1101/2020.04.22.20074963v1 @LifelinesNL @serenasanna1 ACE2 and TMPRSS2 are
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Matt Hall
cispt2
OK so let's talk about camostat, because I'm starting to worry about it as a #COVID19 repurposing candidate. It emerged based on this Cell paper, but a LOT of assumptions
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Sripal_s
sripal_chandra
The COVID targets- RNA virus. SARS COV2 shares nearly 80% genetic analogy with previous SARS COV particularly for spike glycoprotein. There are two subunits of spike glycoprotein but this is
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Rafael Fonseca MD
Rfonsi1
*** COVID19 and males***Is infection with SARS-CoV-2 more virulent among males, and if so why? Can we do anything about it, or use this information for treatment purposes. This thread
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Treponema Pallidum
sulley_ibraheem
Denmark will start a clinical trial of a drug named camostat mesylate tomorrow—barely 1 month after a Cell paper showed the compound can prevent the novel coronavirus, SARS-CoV-2, from entering
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Dr. Angela Rasmussen
angie_rasmussen
New paper shows that smoking cigs increases expression of the #SARSCoV2 receptor ACE2. The idea here is more ACE2, more infection, worse #COVID19.This is a faulty assumption.https://www.atsjournals.org/doi/abs/10.1164/rccm.202003-0693LE#.XqW1P4Cg3FM.
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Dr. Christopher Schmitt
fuzzyatelin
Our paper on #ACE2 and #TMPRSS2 variation–the genes coding for the main receptors for #SARSCoV2 in our cells–in savanna monkeys (genus #Chlorocebus, or #vervets) is just out in @PLOSONE! Let
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Anand Ranganathan
ARanganathan72
Demographic breakdown by Age for India and Italy, and Death Rate by Age for #COVID19. #CoVID19Global Case Fatality Rate (CFR): 3.5%[(3800 deaths / 110,000 confirmed cases) X 100]1. CFR will
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Lu Chen
houndcl
https://clinicaltrials.gov/ct2/results?cond=&term=Camostat&cntry=&state=&city=&dist= 5 Camostat trials proposed based on ∅.If TMPRSS2 not expressed, water-like activity at 50uM. Otherwise, some inhibition at 10uM https://www.biorx
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robert rosencrans
rfrosencrans
In #RaceInABottle, Jonathan Kahn exhaustively documented these studies. Tiny, non-random samples extrapolated to millions. Bad statistics + bad theory. I prefer a different subgroup, repeatedly shown to have biologic import:
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Taiwan Formosa Club 🌐
taiwanformosan
Based on #2019nCoV therapy review (https://f1000research.com/articles/9-72/v2), further evidence was found in the 6 genetic variants associated with higher ratio of ACE2 cells. This weaponized coronavirus appears to be optimized for
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Edward Nirenberg
ENirenberg
Anyone who looks to this charlatan as a source of medical expertise or even as someone with anything resembling scruples is undertaking a fools errand. This is a textbook example
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Dr. Angela Rasmussen
angie_rasmussen
I agree that #SARSCoV2 #COVID19 #coronavirus ocular exposure needs more research, but I'd hold off on assuming that this route is responsible for a substantial portion of new infections for
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Kobayashi Maru
knowing_what_is
Prosac(in german: Antidepressivum Fluoxetin) https://twitter.com/Karl_Lauterbach/status/1295333980301123587 https://twitter.com/Karl_Lauterbach/status/1319643936835751936 Fluoxetin=ProzacFluoxetin in der deutschen Wikipedia:https://de.wikip
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Roxana Daneshjou MD/PhD
RoxanaDaneshjou
I would like to lay out why this work is scientifically unsound and problematic. Note that my PhD was in a genetics/informatics lab, and I spent time working with population
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