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Muscle cramps!
We have all had them
But imagine they woke you up every night
For many people with #cirrhosis, that's life!
A #livertwitter #tweetorial featuring:
Who
Why
What to do
#meded #medtwitter #MedStudentTwitter
1/7
We have all had them
But imagine they woke you up every night
For many people with #cirrhosis, that's life!
A #livertwitter #tweetorial featuring:
WhoWhyWhat to do#meded #medtwitter #MedStudentTwitter
1/7
Cramps in #cirrhosis
Mainly @
,in the
, intense
Common: 1 in 3 people
Risk factors? anyone cramps! No diff in labs!
Turns quality of life into
2/
Mainly @,in the, intenseCommon: 1 in 3 peopleRisk factors? anyone cramps! No diff in labs!Turns quality of life into2/
But why cramps in #cirrhosis
ATP in muscle of ppl w/cirrhosis
ATP needed for myosin to detach from actin
cramping in cirrhosis associated with
plasma volume &
renin activity
Nerve perfusion depends on volume
&vol alsosympathetic nerve activity
3/
ATP in muscle of ppl w/cirrhosisATP needed for myosin to detach from actincramping in cirrhosis associated withplasma volume &renin activityNerve perfusion depends on volume &
vol alsosympathetic nerve activity3/
Muscle cramps suck
So let's treat them
Incomplete list:
plasma volume
Hypertonic IVF works 4 dialysis cramps(Fig1)
some ppl use
Juice
Albumin works for #cirrhosis cramps(Fig2)
(Juice trial pending)
Quinine?(Fig3)
Taurine?(Fig4)
Baclofen?
4/
So let's treat them
Incomplete list:
plasma volumeHypertonic IVF works 4 dialysis cramps(Fig1)some ppl use
JuiceAlbumin works for #cirrhosis cramps(Fig2)(
Juice trial pending)Quinine?(Fig3)Taurine?(Fig4)Baclofen?4/
QUININE
muscle excitability(Fig1)
creates a 'refractory period'
FDA says
use (risk of
disorders)
Taurine
May reduce Ca2+ influx 2 muscle(Fig2)
May work(Fig3)
#RedBull 4 all?
Baclofen
GABA motorneuron signal
May work(Fig4)
5/
muscle excitability(Fig1)creates a 'refractory period'FDA saysuse (risk ofdisorders)Taurine
May reduce Ca2+ influx 2 muscle(Fig2)May work(Fig3) #RedBull 4 all?Baclofen
GABA motorneuron signal May work(Fig4)5/
Cramps in #cirrhosis: a summary
Common (33%)
Causes:
-muscle ATP
-plasma volume
(flow2nerves, vasoconstriction)
Trashes quality of life
Treatable. But first u have to ask!
6/
Common (33%)Causes:-
muscle ATP-
plasma volume(
flow2nerves, vasoconstriction)Trashes quality of lifeTreatable. But first u have to ask!6/
This concludes a #tweetorial on cramps in #cirrhosis
Hope you enjoyed!
I also hope
weawareness of often overlooked symptoms
That we can seize this telehealth moment to focus on what matters most 2 patient, use our video visits 2 solicit & address symptoms
Fin
Hope you enjoyed!
I also hope
weawareness of often overlooked symptomsThat we can seize this telehealth moment to focus on what matters most 2 patient, use our video visits 2 solicit & address symptomsFin
